瘦素在肥胖成人哮喘发病机制中的研究

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摘要目的研究瘦素与肥胖成人哮喘Thl／Th2细胞因子及症状严重程度的相关性，进一步探讨肥胖成人哮喘的发病机制。方法选取2016年7~12月珠海市人民医院（以下简称“我院”）哮喘患者100例为研究对象，按照体重指数（BMI）将其分为肥胖哮喘组、非肥胖哮喘组各50例，选取同期我院健康体检者50例为对照组，并根据BMI分为肥胖组、正常体重对照组各25例。用酶联免疫吸附法（ELISA）测定血清瘦素、γ-干扰素（INF-γ）、白细胞介素-4（IL-4）及肺功能、哮喘控制测试（ACT）评分。分析瘦素与INF-γ、IL-4及肺功能、ACT评分之间的相关性。结果肥胖哮喘组瘦素、IFN-γ、IFN-γ/IL-4水平均高于其他组别（P < 0.05），血清瘦素水平与ACT评分、第一秒用力呼气容积%预计值（FEV1%Pred）呈负相关（r= -0.501、-0.384，均P < 0.05），与IFN-γ、IFN-γ/IL-4呈正相关（r= 0.446、0.423，均P < 0.05），但与IL-4无明显相关性（r= -0.189，P ＞ 0.05）。结论肥胖哮喘组患者较其他组血清瘦素水平更高，与哮喘临床症状严重程度呈正相关，且有可能通过参与Th1型细胞因子所介导的气道高反应性。

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	李俊翁育清曾利恒曾繁睿

关键词 ：瘦素, 肥胖, 哮喘, 细胞因子

Abstract：Objective To observe the correlationship between serum leptin, Th1/Th2 cytokine and symptom severity in obese adult asthma patients, and investigate the pathogenesis of obese adult asthma. Methods From July to December 2016, 100 patients with asthma admitted to the Zhuhai People′s Hospital (“our hospital” for short) were selected as research objects, and they were divided into obese asthma group (50 cases) and non-obese asthma group (50 cases)by BMI. Fifty cases of healthy people at the same time in our hospital for physical examination were selected as control group, and were divided into obese group (25 cases) and non-obese control group (25 cases). Serum leptin, INF-γ and IL-4 were detected using ELISA, as well as did the concurrent pulmonary function and asthma contml test (ACT). The correlationship between serum leptin, INF-γ, IL-4, pulmonary function and ACT was analyzed. Results The serum leptin, IFN-γ and IFN-γ/IL-4 in obese asthma groud were significantly higher than those in other groups (P < 0.05). The leptin levels in obese asthma groud showed a negative correlation with ACT and FEV1%Pred (r= -0.501, -0.384, all P < 0.05), but a positive correlation with IFN-γ and IFN-γ/IL-4 (r= 0.446, 0.423, all P < 0.05), and no correlation with IL-4 (r= -0.189, P ＞ 0.05). Conclusion The serum leptin in obese asthma patients has a higher level and a positive correlation with clinical severity, and probably plays a role in airway hyperresponsiveness by Th1 cytokine mediating.

Key words： Leptin Obesity Asthma Cytokine

基金资助:广东省医学科学技术研究基金项目（B2016120）。

作者简介: 李俊（1972.11-），女，硕士，副主任医师；研究方向：支气管哮喘的发病机制及临床研究。

引用本文:

李俊翁育清曾利恒曾繁睿. 瘦素在肥胖成人哮喘发病机制中的研究[J]. 中国医药导报, 2018, 15(13): 55-58.
LI Jun WENG Yuqing ZENG Liheng ZENG Fanrui. Research on leptin in the pathogenesis of obese adult asthma. 中国医药导报, 2018, 15(13): 55-58.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I13/55

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