Evaluation of clinical efficacy and safety of external application of Chinese herbal medicine fumigation with Eliminating Dampness and Dispelling Cold Decoction for knee osteoarthritis syndrome of cold-dampness due to kidney deficiency
ZHANG Yanzhen1 LU Cong2 ZHANG Chen1 SUN Songge1 QIU Xinping1▲
1.Department of Rheumatology, Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing 101300, China;
2.Department of Endocrinology, Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing 101300, China
Abstract：Objective To evaluate the clinical efficacy and safety of external application of Chinese herbal medicine fumigation with Eliminating Dampness and Dispelling Cold Decoction for knee osteoarthritis of syndrome of cold-dampness due to kidney deficiency. Methods Sixty-eight patients with knee osteoarthritis of syndrome of cold-dampness due to kidney deficiency admitted to Outpatient Department of Rheumatology, Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital from January to October 2017 were selected as research objects. They were divided into treatment group and control group by random number table method. The treatment group was treated with Chinese herbal medicine fumigation with Eliminating Dampness and Dispelling Cold Decoction, the control group was treated with external application of Diclofenac Diethylamine Emulsion, the course of the two groups was 2 weeks. The scores of joint pain (patient evaluation and doctor evaluation), Michel Lequesne index of severity for knee joint osteoarthritis (ISOA), WOMAC osteoarthritis index, and TCM syndrome integral, security indices were observed before and after treatment, so as to evaluate the effect and safety. Results After treatment, the scores of joint pain (patient evaluation) in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the scores of joint pain (patient evaluation) after treatment in the treatment group was lower than the control group (P ＜ 0.05). After treatment, the scores of joint pain (physician evaluation) in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the scores of joint pain (physician evaluation) after treatment in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the scores of ISOA in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the scores of ISOA after treatment in the treatment group were lower than the control group (P ＜ 0.05). After treatment, the scores of WOMAC osteoarthritis index in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the scores of WOMAC osteoarthritis index in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the total scores of TCM syndromes in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the total score of TCM syndromes in the treatment group after treatment was lower than the control group (P ＜ 0.05). After treatment, the clinical efficacy of the treatment group was better than that of control group, the difference was significant (P ＜ 0.05). The efficacy of TCM syndrome of the treatment group was better than that of control group, the difference was statistically different (P ＜ 0.05). No adverse reactions occurred in either group. Conclusion The treatment of Chinese herbal medicine fumigation with Eliminating Dampness and Dispelling Cold Decoction has the effects of relieving symptoms and improving joint function and clinical signs in patients with knee osteoarthritis syndrome of cold-dampness due to kidney deficiency. Its curative effect is more significant than that of external application of Diclofenac Diethylamine Emulsion, and no adverse reactions are found. It is a safe and effective method.
张艳珍1 卢聪2 张辰1 孙颂歌1 邱新萍1▲. 祛湿散寒方中药熏蒸外治肾虚寒湿型膝骨关节炎的效果与安全性评价[J]. 中国医药导报, 2018, 15(16): 105-109.
ZHANG Yanzhen1 LU Cong2 ZHANG Chen1 SUN Songge1 QIU Xinping1▲. Evaluation of clinical efficacy and safety of external application of Chinese herbal medicine fumigation with Eliminating Dampness and Dispelling Cold Decoction for knee osteoarthritis syndrome of cold-dampness due to kidney deficiency. 中国医药导报, 2018, 15(16): 105-109.
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2018, Vol. 15 
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