胆维丁乳预防儿童反复呼吸道感染的随机对照研究

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摘要目的研究胆维丁乳对儿童反复呼吸道感染发病率的影响。方法将2015年7月~2016年7月重庆市合川区人民医院儿科门诊及住院部的100例反复呼吸道感染患儿采用随机数字表法分为维生素D（Vit D）组（50例）和对照组（50例）。Vit D组予胆维丁乳8 mL/次口服，间隔2个月1次，共4次；对照组给予安慰剂。随访1年，检测两组治疗前及治疗1年后Vit D水平，比较两组出院后呼吸道感染次数、呼吸道感染住院率、呼吸道感染后恢复时间，分析Vit D与呼吸道感染的关系。结果两组治疗前Vit D水平比较差异无统计学意义（P > 0.05）；治疗1年后Vit D组Vit D水平显著高于对照组（P ＜ 0.01），其出院后呼吸道感染次数少于对照组（P ＜ 0.01），呼吸道感染住院率低于对照组（P ＜ 0.05），呼吸道感染后恢复时间短于对照组（P ＜ 0.05）。相关分析结果显示，治疗前后患儿Vit D水平与呼吸道感染均呈负相关（r = -0.78、-0.82，均P ＜ 0.01）。Logistic回归分析结果显示，较高的Vit D水平是儿童反复呼吸道感染的保护因素（矫正OR = 0.84，95%CI：0.78~0.90，P ＜ 0.01）。结论胆维丁乳能明显提高儿童Vit D水平，减少儿童反复呼吸道感染。

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	文静郭梅周宏赵静蒙燕马月李渝华▲

关键词 ：胆维丁乳, 儿童, 呼吸道感染, 维生素D

Abstract：Objective To study the effect of cholecalciterol cholesterol emulsion (CCE) on the incidence of recurrent respiratory infections (RRI) among children. Methods From July 2015 to July 2016, 100 children with RRI in the Department of Pediatrics at the People's Hospital of Hechuan District of Chongqing City were divided into Vit D group (50 cases) and control group (50 cases) by random number tabel. Children in the Vit D group were given oral CCE, 8 mL each time, one time every two months, for 4 times; children in control group were given Placebo. Children were followed-up for one year, levels of serum Vit D before and one year after treatment were measured, the frequency of respiratory infections, hospitalization, and recovery time were compared. Results There was no statistically significant difference in level of serum Vit D between the two groups before treatment (P > 0.01). One year after treatment, level of serum Vit D in Vit D group were significantly higher than that in control group (P ＜ 0.01). The frequency of respiratory infections post-discharge and hospitalization rate due to RRI was significantly lower in Vit D group compared with control group (P ＜ 0.05 or P ＜ 0.01). The recovery time from RRI in Vit D group was significantly shorter than that of control group (P ＜ 0.05). Multivariate Logistic regression analysis results showed that higher Vit D level was a protective factor for RRI (OR = 0.84, 95%CI: 0.78-0.90, P ＜ 0.01). Conclusion CCE can significantly increase serum Vit D among RRI children, and decrease the frequency of respiratory infections in children with RRI.

Key words： Cholecalciterol cholesterol emulsion Children Recurrent respiratory infections Vitamin D

基金资助:重庆市卫计委医学科研项目（2015ZBXM016）。

通讯作者: ▲通讯作者

引用本文:

文静郭梅周宏赵静蒙燕马月李渝华▲. 胆维丁乳预防儿童反复呼吸道感染的随机对照研究[J]. 中国医药导报, 2018, 15(21): 82-85.
WEN Jing GUO Mei ZHOU Hong ZHAO Jing MENG Yan MA Yue LI Yuhua▲. Cholecalciterol cholesterol emulsion supplementation for the prevention of recurrent respiratory infections: a randomized, controlled trial among children. 中国医药导报, 2018, 15(21): 82-85.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I21/82

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