The value of color Doppler ultrasonography in the evaluation of diabetic lower extremity vascular disease and its relationship with serum Lp-PLA2，25 （OH） D3 levels
CHENG Qi1 TAN Yongpan2 SONG Quan1 HE Yufang3
1.Department of Function, the First Hospital of Shijiazhuang, Hebei Province, Shijiazhuang 050010, China;
2.Department of Ultrasound, the Fourth Hospital of Shijiazhuang, Hebei Province, Shijiazhuang 050010, China;
3.Department of Ultrasound, the First Hospital of Shijiazhuang, Hebei Province, Shijiazhuang 050010, China
Abstract：Objective To study the value of color Doppler ultrasonography in the evaluation of diabetic lower extremity vascular disease and its relationship with serum lipoprotein related phospholipase A2 (Lp-PLA2) and 25-hydroxyvitamin D3 [25(OH)D3] levels. Methods From February 2015 to February 2016, 200 patients with diabetes in the First Hospital of Shijiazhuang were divided into group A with 43 cases of diabetic lower extremity vascular disease, group B with 157 cases of no diabetic lower extremity vascular disease according to color Doppler ultrasonography examination results. And 40 cases of healthy check-up were selected as healthy control group. The arterial diameter and arterial blood flow in each group was examined by color Doppler ultrasonography, and serum Lp-PLA2, 25(OH)D3 levels were detected by enzyme-linked immunosorbent assay, Pearson correlation analysis was used to analyze the association between artery diameter and blood flow, serum Lp-PLA2, 25 (OH)D3. Results The femoral artery, popliteal artery, dorsalis pedis artery diameter of group A were significantly lower than those of group B and healthy control group, and femoral artery, popliteal artery, dorsalis pedis artery blood flow were significantly lower than those of group B and healthy control group (P < 0.05), the above indexes were not statistically different between the healthy control group and the group B (P > 0.05). The level of serum Lp-PLA2 in group A was significantly higher than that of group B and control group, 25 (OH)D3 level was significantly lower than group B and healthy control group (P < 0.05), while there was no significant difference in levels of Lp-PLA2 and 25 (OH)D3 between the healthy control group and group B (P > 0.05). The vascular diameter and blood flow of patients with lower extremity arterial disease related to diabetic were positively correlated with the level of serum Lp-PLA2 (r = 0.562, 0.621, P ＜ 0.05）, and was negatively correlated with the level of 25 (OH)D3 (r = -0.663, -0.582, P ＜ 0.05). Conclusion Patients with diabetic lower extremity vascular disease show the presence of lower extremity arterial stenosis, slow flow of blood, and abnormal changes in serum Lp-PLA2 and 25 (OH)D3 levels. The intra arterial diameter and arterial blood flow are closely related to the levels of serum Lp-PLA2 and 25 (OH)D3.
程琦1 檀永攀2 宋全1 何玉芳3. 彩色多普勒超声对糖尿病下肢血管病变的评估价值及与血清Lp-PLA2、25（OH）D3水平的关系[J]. 中国医药导报, 2018, 15(22): 123-126.
CHENG Qi1 TAN Yongpan2 SONG Quan1 HE Yufang3. The value of color Doppler ultrasonography in the evaluation of diabetic lower extremity vascular disease and its relationship with serum Lp-PLA2，25 （OH） D3 levels. 中国医药导报, 2018, 15(22): 123-126.
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2018, Vol. 15 
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