软坚散结方外敷联合泡沫硬化治疗下肢静脉性溃疡的效果

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摘要目的探讨软坚散结方外敷联合泡沫硬化治疗下肢静脉性溃疡的效果。方法选择甘肃省第二人民医院2014年6月～2015年9月收治的79例原发性下肢静脉曲张伴活动性溃疡患者，将其随机分为观察组（39例）和对照组（40例）。两组均进行术前检查及泡沫硬化治疗，观察组在此基础上采用软坚散结方外敷治疗。疗程1个月。对患者进行随访，采用慢性静脉功能不全生活质量问卷调查表（CIVIQ）及静脉疾病临床严重程度评分系统（VCSS）分别评定患者入院时、出院时、出院后1个月、6个月内CIVIQ及VCSS得分，观察两组治疗效果及手术相关并发症的发生情况。结果不同时间点，观察组和对照组组内CIVIQ评分不断升高（F = 13.242、7.543，均P ＜ 0.05）；观察组组内VCSS评分不断降低（F = 12.009，P ＜ 0.05）。所有患者均成功完成随访，至随访结束，观察组治疗效果明显优于对照组（P ＜ 0.05）。观察组在1个月时的术区肿痛比例及6个月时的静脉炎、创面感染、术区肿痛比例明显低于对照组（P ＜ 0.05）。结论软件散结方外敷联合泡沫硬化治疗下肢静脉性溃疡可明显改善溃疡创面及周边皮肤血运情况，降低并发症发生率，提高其生活质量。

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关键词 ：下肢静脉性溃疡, 软坚散结方, 外敷, 泡沫硬化

Abstract：Objective To investigate the curative effect of Ruanjian Sanjie Prescription combined with bubble hardening in the treatment of lower limb venous ulcer. Methods Seventy-nine cases of primary varicose veins of lower limbs with active ulcer patients admitted to the Second People's Hospital of Gansu Province from June 2014 to September 2019 were selected and randomly divided into observation group (39 cases) and control group (40 cases). Both groups were given preoperative examination and foam sclerotherapy, on basis of which, the observation group was given external application of Ruanjian Sanjie Prescription. The course was one month. The patients were followed up, the chronic venous insufficiency questionnaire of quality of life (CIVIQ) and venous disease clinical severity score (VCSS) were used respectively to assess the scores of CIVIQ and VCSS on admission and at discharge, 1 month, 6 months after discharge. The therapeutic effect and complications related to the operation of the two groups were observed. Results At different time points, the scores of CIVIQ in the observation group and control group were increased (F = 13.242, 7.543, P ＜ 0.05). The VCSS score in the observation group was decreased continuously (F = 12.009, P ＜ 0.05). All patients were successfully followed up to the end of the follow-up period, and observation group was significantly better than the control group (P ＜ 0.05). The proportion of the swelling pain in the 1 month period and the proportion of venous inflammation, infection of the wound, and the swelling of the operative area in the 6 months period were significantly lower than those in control group (P ＜ 0.05). Conclusion Ruanjian Sanjie Prescription combined with bubble hardening in the treatment of lower limb venous ulcer can obviously improve the conditions of ulcer wound and the surrounding skin blood supply, reduce the incidence of complications, and improve their quality of life.

Key words： Lower limb venous ulcer Ruanjian Sanjie Prescription External application Bubble hardening

基金资助:西北民族大学中央高校基本科研业务费专项资金资助项目（31920150094）。

通讯作者: 冯智军（1986.10-），男，硕士；研究方向：外周介入治疗。

引用本文:

郭海国1,2 冯智军1,2 王骏臣1,2 李月春1,2 胡玮1,2 余新林1,2 张慧芳1,2. 软坚散结方外敷联合泡沫硬化治疗下肢静脉性溃疡的效果[J]. 中国医药导报, 2017, 14(31): 88-91.
GUO Haiguo1,2 FENG Zhijun1,2 WANG Junchen1,2 LI Yuechun1,2 HU Wei1,2 YU Xinlin1,2 ZHANG Huifang1,2 WANG Ruiju1,2. Curative effect of Ruanjian Sanjie Prescription combined with bubble hardening in the treatment of lower limb venous ulcer. 中国医药导报, 2017, 14(31): 88-91.

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