Abstract：Objective To evaluate the effect of vitamin B12, folic acid combined with Metformin on type 2 diabetes and its effect on homocysteine. Methods From January 2016 to January 2017, 66 newly diagnosed patients with type 2 diabetes, who were diagnosed and treated in Beijing Aerospace Hospital were selected as the subjects. The randomized digital table method was used to divide them into the control group and the observation group, with 33 cases in each group. The control group was treated with Metformin only, while the observation group was treated with vitamin B12 and folic acid combined with Metformin. Vitamin B12, folic acid and homocysteine levels were compared between the two groups after 8 and 12 weeks′ treatment. Results Before treatment, there was no significant difference in the content of folic acid, vitamin B12 and level of homocysteine in these two groups (P > 0.05). After 8 and 12 weeks of treatment, the content of folic acid and the level of homocysteine in the observation group had no obvious change, while the content of vitamin B12 increased obviously. The content of folic acid and vitamin B12 in the control group were more than those of the before treatment, the level of homocysteine was increased, and the differences were statistically significant (P < 0.05). Conclusion Compared with Metformin alone, the treatment of vitamin B12, folic acid and Metformin can effectively stabilize the level of homocysteine in the patients with type 2 diabetes.
2018, Vol. 15 
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