Exploration on the medication rules of traditional Chinese medicine in the treatment of high risk human papilloma virus infection based on data mining#br#
LIN Qiuping1 ZHAO Chunjing2 HUANG Zhongming3 QUAN Kewei2 WANG Naiping2
1.Graduate School, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2.Department of Obstetrics and Gynecology, Dongguan Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Dongguan 523000, China;
3.the First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China
Abstract：Objective To explore the medication rules of traditional Chinese medicine in the treatment of high risk human papilloma virus (HR-HPV) infection. Methods Effective prescriptions for HR-HPV infection were collected from CNKI, Wanfang and VIP databases, and the retrieval time was from January 2000 to February 2021. The frequency and nature of traditional Chinese medicine (four qi, five flavors, meridian entry) were counted by using cloud platform of ancient and modern medical records; SPSS Modeler 18.0 was used for cluster analysis and association rule analysis, and a complex network of traditional Chinese medicine was build to screen the core combination of traditional Chinese medicine. Results A total of 95 prescriptions were included, involving 152 kinds of traditional Chinese medicine, of which tonifying and replenishing medicine, heat-clearing medicine and dampness-draining medicine were the most common. The main meridian entries were liver and spleen, the four qi was mainly cold and flat, the five flavors were mainly sweet and bitter. High-frequency traditional Chinese medicine were divided into seven groups by cluster analysis, and 20 pairs of drug combinations were screened out by association analysis. Eight drugs which were Astragali Radix, Atractylodis Macrocephalae Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, Hedyotis, Codonopsis Radix, Poria and Glycyrrhizae Radix et Rhizoma found by complex network were the core prescriptions for the treatment of HR-HPV infection. Conclusion The basic principles of traditional Chinese medicine in the treatment of HR-HPV infection are “invigorating spleen for eliminating dampness, clearing heat and removing toxicity”, and nourishing and promoting blood circulation, and the main drugs are tonifying and replenishing medicine, heat-clearing medicine and dampness-draining medicine.
林秋平1 赵春景2 黄重铭3 全克违2 王乃平2. 基于数据挖掘探讨中药治疗高危型人乳头瘤病毒感染的用药规律[J]. 中国医药导报, 2022, 19(4): 119-123.
LIN Qiuping1 ZHAO Chunjing2 HUANG Zhongming3 QUAN Kewei2 WANG Naiping2. Exploration on the medication rules of traditional Chinese medicine in the treatment of high risk human papilloma virus infection based on data mining#br#. 中国医药导报, 2022, 19(4): 119-123.
[1] Chen WQ. Cancer statistics： updated cancer burden in China [J]. Chin J Cancer Res，2015，27（1）：1.
[2] Herrero R，González P，Markowitz LE. Present status of human papillomavirus vaccine development and implementation [J]. Lancet Oncol，2015，16（5）：e206-e216.
[3] Sanjose SD，Quint WG，Alemany L，et al. Human papillomavirus genotype attribution in invasive cervical cancer：a retrospective cross-sectional worldwide study [J]. Lancet Oncol，2010，11（11）：1048-1056.
[4] 李杏婵，何雅婷，赵愚.高危型HPV感染与宫颈癌前病变、宫颈癌的关系分析[J].中国医药科学，2020，10（16）：71-73.
[5] 毛莉，史晓敏，徐芬燕.阴道微环境和IL-10水平变化与高危型HPV感染的关系[J].中国现代医生，2020，58（7）：1-5.
[6] 郭爱霞，李红林，刘小宁.淮安地区妇女高危型HPV感染现状分析[J].中国现代医生，2020，58（14）：136-139.
[7] 黄红香，顾建全，闫洪超.外用红色诺卡氏菌细胞壁骨架治疗宫颈持续高危型HPV感染的临床效果[J].中国医药导报，2020，17（36）：119-122.
[8] 何玥，吴玉梅，王彤，等.妊娠合并子宫颈上皮内瘤变患者高危型HPV感染的临床研究[J].中华妇产科杂志，2012，47（8）：598-602.
[9] 徐帅师，聂文佳，张咏梅.宫颈人乳头瘤病毒感染治疗方法研究进展[J].病毒学报，2021，37（3）：740-747.
[10] 覃晓洵，钱麟.中医药治疗宫颈人乳头瘤病毒感染的临床研究进展[J].河北中医，2018，40（10）：1596-1600.
[11] 林寒梅，马平兰.中医治疗宫颈HPV感染概况[J].实用中医药杂志，2011，27（10）：732-733.
[12] 王琳，姜晓春，陈瑶，等.高危型人乳头瘤病毒持续感染与中医体质的相关性研究[J].陕西中医药大学学报，2019， 42（2）：111-114.
[13] 刘君，李娅，马秀丽，等.宫颈高危型人乳头瘤病毒感染者中医体质相关性研究[J].世界中西医结合杂志，2019， 14（12）：1649-1651，1715.
[14] 朱建楠，朱艳.黄芪用于阻断宫颈癌前病变机制的研究[J].中国全科医学，2014，17（13）：1562-1564.
[15] Georgescu SR，Mitran CI，Mitran MI，et al. New insights in the pathogenesis of HPV infection and the associated carcinogenic processes：the role of chronic inflammation and oxidative stress [J]. J Immunol Res，2018，2018：5315816.
[16] Kemp TJ，Hildesheim A，García-Pi?觡eres A，et al. Elevated systemic levels of inflammatory cytokines in older women with persistent cervical human papillomavirus infection [J]. Cancer Epidemiol Biomarkers Prev，2010，19（8）：1954-1959.
[17] 王信，马传江，杨培民，等.白花蛇舌草抗炎、抗肿瘤作用研究进展[J].中国现代应用药学，2020，37（19）：2420-2427.
[18] 张培影，王业桥，徐侠，等.白花蛇舌草对裸鼠宫颈癌细胞增殖和凋亡的实验研究[J].中国当代医药，2010，17（30）：5-8.
[19] 雷雪霏.黄柏炮制前后药代动力学及质变成分药效作用研究[D].沈阳：辽宁中医药大学，2018.
[20] Zhang C，Zhang W，Shi R，et al. Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model [J]. Pharm Biol，2019，57（1）：792-798.
京公网安备 11010502046598号