不同试管婴儿技术对妊娠期肝内胆汁淤积症发病率的影响

摘要
图/表
参考文献(21)
相关文章 (0)

全文: PDF (858 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨不同试管婴儿技术对妊娠期肝内胆汁淤积症（ICP）发病率的影响。方法收集整理2013年1月~2015年12月在首都医科大学附属北京妇产医院住院分娩的辅助生殖技术（ART）治疗后妊娠产妇2256例的临床资料。根据不同的受精方式分为体外受精-胚胎移植（IVF）组（1873例）和胞浆内单精子注射（ICSI）组（383例）；根据不同的胚胎转移周期分为新鲜胚胎移植（Fresh）组（1483例）和冷冻胚胎移植（FET）组（773例）。分析各组患者不孕不育的原因及不同试管婴儿技术ICP发病率。结果 ICSI组ICP发病率略高于IVF组，但差异无统计学意义（χ2 = 0.01，P = 0.89）。FET组ICP发病率略高于Fresh组，但两组差异无统计学意义（χ2 = 0.28，P = 0.59）。结论接受 ICSI技术后ICP患病风险不会升高。ICP的发病风险与胚胎移植前是否进行冻融无关。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	雷玲玲梁毓王树玉

关键词 ：试管婴儿, 妊娠期肝内胆汁淤积症, 卵泡浆内单精子注射, 冷冻周期胚胎移植

Abstract：Objective To investigate the effect of different test-tube baby technology on the incidence of intrahepatic cholestasis of pregnancy (ICP). Methods Clinical data of 2256 pregnancy women after the treatment of assisted reproductive technology at Beijing Obstetrics and Gynecology Hospital from January 2013 to December 2015 were collected. According to different fertilization modes, patients were divided into in vitro fertilization group (IVF group, 1873 cases) and intracytoplasmic sperm injection group (ICSI group, 383 cases). According to different embryo transfer cycle, patients were divided into fresh embryo transfer (Fresh group, 1483 cases) and frozen-thawed embryo transfer group (FET group, 773 cases). Reasons of infertility and incidence of ICP of patients in each groups were analyzed. Results The incidence of ICP in the ICSI group was slightly higher than that in the IVF group, but the difference between the two groups was no statistically significant (χ2 = 0.01, P = 0.89). The incidence of ICP in the FET group was slightly higher than that in the Fresh group, but the difference between the two groups was no statistically significant (χ2 = 0.28, P = 0.59). Conclusion ICSI fertilization does not increase the risk of intrahepatic cholestasis during pregnancy. Whether or not frozen thawed prior to embryo transfer is not associated with intrahepatic cholestasis during pregnancy.

Key words： Test-tube baby Intrahepatic cholestasis during pregnancy Intracytoplasmic sperm injection Frozen-thawed embryo transfer

基金资助:北京市医院管理局“青苗”计划专项资助项目（QML20161402）；
首都医科大学附属北京妇产医院青年基金专项资助项目（FCYYQN-201508）。

通讯作者: 王树玉（1957.3-），女，博士，主任医师；研究方向：生殖医学及遗传学。

作者简介: 雷玲玲（1980.2-），女，硕士；研究方向：生殖医学。

引用本文:

雷玲玲梁毓王树玉. 不同试管婴儿技术对妊娠期肝内胆汁淤积症发病率的影响[J]. 中国医药导报, 2018, 15(26): 74-76,89.
LEI Lingling LIANG Yu WANG Shuyu. Effect of different test-tube baby technology on the incidence of intrahepatic cholestasis of pregnancy. 中国医药导报, 2018, 15(26): 74-76,89.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I26/74

[1] Farhi A，Reichman B，Boyko V，et al. Maternal and neonatal health outcomes following assisted reproduction [J]. Reprod Bio Med Online，2013，26（5）：454-461.
[2] Jackson S，Hong C，Wang ET，et al. Pregnancy outcomes in very advanced maternal age pregnancies：the impact of assisted reproductive technology [J]. Fertil Steril，2015， 103（1）：76-80.
[3] Šljivan■anin T，Konti■-Vu■ini■ O. Perinatal outcomes of pregnancies conceived by assisted reproductive technologies [J]. Srp Arh Celok Lek，2015，143（9-10）：632-638.
[4] Malchau SS，Loft A，Henningsen AK，et al. Perinatal outcomes in 6，338 singletons born after intrauterine insemination in Denmark，2007 to 2012：the influence of ovarian stimulation [J]. Fertil Steril，2014，102（4）：1110-1116.
[5] Li Z，Wang YA，Ledger W，et al. Birthweight percentiles by gestational age for births following assisted reproductive technology in Australia and New Zealand，2002-2010 [J]. Hum Reprod，2014，29（8）：1787-1800.
[6] Qin J，Liu X，Sheng X，et al. Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancy outcomes in singleton pregnancies：a meta-analysis of cohort studies [J]. Fertil Steril，2016， 105（1）：73-85.
[7] ümit G，Izetbegovic S，Admir R，et al. Causes of sterility in bosnia-herzegovina population [J]. Mater Sociomed，2015， 27（3）：185-187.
[8] Messerlian C，Platt RW，Ata B，et al. Do the causes of infertility play a direct role in the aetiology of preterm birth? [J]. Paediatr Perinat Epidemiol，2015，29（2）：101-112.
[9] Eiss D，Cornud F，Thiounn N，et al. Imaging of male infertility：techniques and results [J]. Gynecol Obstet Fert，2012， 40（9）：481-489.
[10] Elbardisi H，Majzoub A，Al Said S，et al. Geographical differences in semen characteristics of 13 892 infertile men [J]. Arab J Urol，2018，16（1）：3-9.
[11] O′Brien YM，Ryan M，Martyn F，et al. A retrospective study of the effect of increasing age on success rates of assisted reproductive technology [J]. Int J Gynaecol Obstet，2017， 138（1）：42-46.
[12] Wennberg AL，Opdahl S，Bergh C，et al. Effect of maternal age on maternal and neonatal outcomes after assisted reproductive technology [J]. Fertil Steril，2016，106（5）：1142-1149.
[13] Vale-Fernandes E，Póvoa AM，Soares S，et al. Assisted Reproductive Technology in Female Transplant Recipients：Experience of a Reproductive Medicine Unit and Literature Review [J]. Acta Med Port，2016，29（1）：73-78.
[14] Dhalwani NN，Boulet SL，Kissin DM，et al. Assisted reproductive technology and perinatal outcomes：conventional versus discordant-sibling design [J]. Fertil Steril，2016，106（3）：710-716.
[15] Frati P，Foldes-Papp Z，Panici PB，et al. A Retrospective Study on Advanced Maternal Age and Assisted Reproductive Techniques，Medico-Legal Advice，"Food for Thought" [J]. Curr Pharm Biotechnol，2016，17（4）：330-336.
[16] Durairajanayagam D. Lifestyle causes of male infertility [J]. Arab J Urol，2018，16（1）：10-20.
[17] Bamberg C，Fotopoulou C，Neissner P，et al. Maternal characteristics and twin gestation outcomes over 10 years：impact of conception methods [J]. Fertil and Steril，2012， 98（1）：95-101.
[18] Fan C，Sun Y，Yang J，et al. Maternal and neonatal outcomes in dichorionic twin pregnancies following IVF treatment：a hospital-based comparative study [J]. Int J Clin Exp Pathol，2013，6（10）：2199-2207.
[19] Esteves SC，Roque M，Bradley CK，et al. Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen：systematic review and meta-analysis [J]. Fertil Steril，2017，108（3）：456-467.
[20] Vaegter KK，Lakic TG，Olovsson M，et al. Which factors are most predictive for live birth after in vitro fertilization and intracytoplasmic sperm injection （IVF/ICSI） treatments? Analysis of 100 prospectively recorded variables in 8，400 IVF/ICSI single-embryo transfers [J]. Fertil Steril. 2017，107（3）：641-648.
[21] Pocate-Cheriet K，Heilikman I，Porcher R，et al. Predicting the clinical outcome of ICSI by sperm head vacuole examination [J]. Syst Biol Reprod Med，2017，63（1）：29-36.