疏肝健脾针刺法对肿块型肉芽肿性小叶性乳腺炎患者免疫功能的影响

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摘要目的观察疏肝健脾针刺法对肿块型肉芽肿性小叶性乳腺炎患者免疫功能的影响。方法选取80例南方医科大学附属深圳妇幼保健院中医科门诊及乳腺科门诊就诊的肿块型肉芽肿性小叶性乳腺炎患者，采用随机数字表法分为治疗组（40例）和对照组（40例）。对照组予醋酸泼尼松片口服，治疗组在对照组的基础上加疏肝健脾针刺法治疗。治疗3个月后评价两组临床疗效，比较两组临床症状及免疫指标[血清T淋巴细胞群（CD3、CD4、CD8）]、免疫球蛋白（Ig）G、IgA、IgM、补体C3及补体C4。结果治疗组总有效率高于对照组（P ＜ 0.05）。治疗后两组乳房肿块大小较治疗前减小，且治疗组小于对照组（P ＜ 0.05）；治疗后两组视觉模拟评分法评分较治疗前降低，且治疗组低于对照组（P ＜ 0.05）。治疗后两组血清CD3、CD4水平均低于治疗前，且治疗组低于对照组（P ＜ 0.05）。治疗后两组血清CD8水平高于治疗前，且治疗组高于对照组（P ＜ 0.05）。治疗后两组血清IgG、IgA、IgM、补体C3、补体C4水平均低于治疗前，且治疗组低于对照组（P ＜ 0.05）。结论疏肝健脾针刺法可有效改善肿块型肉芽肿性小叶性乳腺炎患者血清免疫指标，平衡免疫功能，临床疗效优于单纯口服醋酸泼尼松片。

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	胡珊刘昱磊陈鹏典陈妍王俊玲宁艳

关键词 ：疏肝健脾针刺法, 肿块型, 肉芽肿性小叶性乳腺炎, 免疫功能

Abstract：Objective To observe the effect of acupuncture method of soothing the liver and fortifying the spleen on immune function of patients with granulomatous lobular mastitis. Methods Eighty patients with lump type granulomatous lobular mastitis were selected from the outpatient department of traditional Chinese medicine and the outpatient department of mammary gland of Shenzhen Maternity & Child Healthcare Hospital Affiliated to Southern Medical University, the patients were divided into treatment group (40 cases) and control group (40 cases) by random number table method. The control group was given oral Prednisone Acetate Tablets, the treatment group was treated with the acupuncture method of soothing the liver and fortifying the spleen on the basis of the control group. After three months of treatment, clinical efficacy of the two groups was evaluated, the clinical symptoms and immune indexes [serum T lymphocyte population (CD3, CD4, CD8)], immunoglobulin (Ig) G, IgA, IgM, complement C3, and complement C4 were compared between the two groups. Results The total effective rate in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the size of breast lump in the two groups was smaller than that before treatment, and that in the treatment group was smaller than that in the control group (P ＜ 0.05). Visual analogue scale scores of the two groups after treatment were lower than those before treatment, and those in the treatment group was lower than those in the control group (P ＜ 0.05). After treatment, the levels of serum CD3 and CD4 in the two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P ＜ 0.05). Serum CD8 level in the two groups after treatment was higher than that before treatment, and that in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the levels of serum IgG, IgA, IgM, complement C3, and complement C4 in the two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P ＜ 0.05). Conclusion Acupuncture method of “soothing the liver and fortifying the spleen” could improve the serum immune indexes of patients with lumpy type granulomatous lobular mastitis, and balance the immune function. The clinical effect is better than oral Prednisone Acetate Tablets alone.

Key words： Acupuncture method of soothing the liver and fortifying the spleen Lump type Granulomatous lobular mastitis Immune function

基金资助:广东省深圳市卫生系统科研项目（SZFZ2018046）；
王俊玲广东省名中医传承工作室（粤中医办函〔2019〕5号）。

通讯作者: 宁艳（1976-），女，博士，主任中医师，硕士生导师；研究方向：中医药防治女性生殖障碍的临床与基础研究。

作者简介: 胡珊（1987-），女，硕士；研究方向：针药结合防治女性疾病。

引用本文:

胡珊刘昱磊陈鹏典陈妍王俊玲宁艳. 疏肝健脾针刺法对肿块型肉芽肿性小叶性乳腺炎患者免疫功能的影响[J]. 中国医药导报, 2022, 19(13): 131-135.
HU Shan LIU Yulei CHEN Pengdian CHEN Yan WANG Junling NING Yan. Effect of acupuncture method of soothing the liver and fortifying the spleen on immune function of patients with granulomatous lobular mastitis#br#. 中国医药导报, 2022, 19(13): 131-135.

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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I13/131

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