Prognostic value of inflammatory indexes, NLR, PLR, red blood cell distribution width level detection in prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease and type Ⅱ respiratory failure
WANG Hongjun1 CHU Qingxia1 MA Dawen1 QIN Yan2▲#br#
1.Department of Respiratory and Critical Care Medicine, Pukou Branch of Jiangsu Province Hospital, Jiangsu Province, Nanjing 211800, China;
2.Department of Respiratory and Critical Care Medicine, Nanjing First Hospital, Jiangsu Province, Nanjing 20006, China
Abstract：Objective To explore the inflammatory indicators and detection of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with type Ⅱ respiratory failure and clinical significance.
Methods A total of 216 patients with AECOPD and type Ⅱ respiratory failure admitted to the Pukou Branch of Jiangsu Province Hospital from June 2018 to May 2021 were selected as the research objects. The survival status of patients with AECOPD combined with type Ⅱ respiratory failure at 28 d after hospitalization was calculated. The general data of the patients in the death group and the survival group were compared. Logistic multivariate regression analysis of factors affecting the prognosis of patients. The value of inflammatory indicators, NLR, PLR, and RDW in predicting the prognosis of patients was analyzed. Results AECOPD patients with type Ⅱ respiratory failure during hospitalization death rate was 15.74%. Multivariate results showed that acute physiology and chronic health status scoring system Ⅱ score (OR = 2.787, 95%CI:1.246-5.213), C-reactive protein (CRP) (OR = 3.374, 95%CI:1.875-5.964), NLR (OR = 4.336, 95%CI:2.943-8.475), PLR (OR = 3.865, 95%CI:2.306-7.815), and RDW (OR = 2.751, 95%CI:1.028-3.957) were risk factors for death (P ＜ 0.05). Receiver operating characteristic curve analysis showed that the area under the curve of CRP, NLR, PLR, and RDW for predicting death in AECOPD patients with type Ⅱ respiratory failure were 0.731 (95%CI:0.666-0.789), 0.796 (95%CI:0.736-0.848), 0.768 (95%CI:0.706~0.823), 0.808 (95%CI:0.749~0.858), respectively. Conclusion CRP, NLR, PLR, and RDW have high predictive power for the death of AECOPD patients with type Ⅱ respiratory failure.
王宏俊1 褚庆霞1 马大文1 谭焰2▲. 炎症指标及NLR、PLR、红细胞分布宽度水平检测对慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭患者预后的预测价值[J]. 中国医药导报, 2022, 19(17): 155-158.
WANG Hongjun1 CHU Qingxia1 MA Dawen1 QIN Yan2▲. Prognostic value of inflammatory indexes, NLR, PLR, red blood cell distribution width level detection in prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease and type Ⅱ respiratory failure. 中国医药导报, 2022, 19(17): 155-158.
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