Analysis of the research situation of osteoarthritis and autophagy based on bibliometrics
YUAN Changshen1 LI Zhe2 GUAN Yanbing2 LIAO Shuning2 CHEN Lewei2 RONG Weiming2 MEI Qijie1 DUAN Kan1#br#
1.Department of Orthopedics of Joint Trauma, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530023, China;
2.Graduate School, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530000, China
Abstract：Objective To discuss the research trend of osteoarthritis (OA) and autophagy, sort out the development history of this field, analyze the current research trends and hotspots, and to make a systematic review and trend prospect of the research in the field of OA and autophagy, so as to provide reference for follow-up research. Methods Based on the PubMed literatures database, bibliometric methods were used to conduct literature analysis and big data mining on OA and autophagy research from January 2011 to December 2021 by the citexs data analysis platform. Results The search obtained 480 valid literatures, and the analysis found that the annual publication volume in this field was increasing continuously, reaching a peak of 108 literatures in 2021, of which the country with the largest number of publications is China (207 literatures, 43.13%), and the research institution was the largest number of publications for the Scripps Research Institute in the United States. The journal with the most literature in this field was Osteoarthritis Cartilage (24 literatures), with a single author publishing up to four literatures, and Chinese scholars had contributed the most in this area. The keywords with the highest frequency in the searched literature were autophagy, apoptosis, chondrocytes, inflammation, and cartilage, and the most associated gene was MTOR (143 literatures). In addition, a total of 15 recommended literatures were also list in this study. Conclusion Research in this field is in a stage of rapid growth, and the research content continues to deepen over time. Although the relevant mechanisms are currently unclear, autophagy as a therapeutic target for OA will have broad clinical prospects, and targeting the complex oxidative stress signaling pathway or regulating MTOR intervention may be an effective way to treat OA.
袁长深1 李哲2 官岩兵2 廖书宁2 陈乐伟2 容伟明2 梅其杰1 段戡1. 基于文献计量的骨关节炎与自噬研究态势分析[J]. 中国医药导报, 2022, 19(24): 5-10,21.
YUAN Changshen1 LI Zhe2 GUAN Yanbing2 LIAO Shuning2 CHEN Lewei2 RONG Weiming2 MEI Qijie1 DUAN Kan1. Analysis of the research situation of osteoarthritis and autophagy based on bibliometrics. 中国医药导报, 2022, 19(24): 5-10,21.
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