Clinical effect of high frequency oscillatory ventilation combined with calf pulmonary surfactant in the treatment of neonatal with acute respiratory distress syndrome
LI Jie ZHANG Hehua LI Lei LI Shuai▲#br#
Department of Neonatology, Fuyang Women’s and Children’s Hospital, Anhui Province, Fuyang 236000, China
Abstract：Objective To investigate the clinical effect of high frequency oscillatory ventilation (HFOV) combined with calf pulmonary surfactant in the treatment of neonatal acute respiratory distress syndrome (ARDS). Methods From January 2018 to June 2021, 80 cases of neonatal ARDS who received ventilator-assisted ventilation in Neonatal Intensive Care Unit of Fuyang Women’s and Children’s Hospital, Anhui Province were selected as the research subjects. They were divided into study group (48 cases, HFOV combined with calf pulmonary surfactant) and control group (32 cases, conventional mechanical ventilation combined with calf pulmonary surfactant) by coin toss method. The treatment effect (ventilator use time, oxygen days after weaning, and hospitalization days) were compared between the two groups; the improvement of blood gases (arterial partial pressure of oxygen [PaO2], arterial partial pressure of carbon dioxide [PaCO2], oxygenation index [OI], and respiratory index [RI]) during ventilation, ventilation lasted for 12, 24, 48, and 72 h were compared between two groups; the occurrence of complications was observed. Results The ventilator use time, oxygen days after weaning, and hospitalization days in study group were shorter than those in control group, and the differences were statistically significant (P < 0.05). Pairwise comparison of PaO2, PaCO2, OI, and RI at different time points between two groups showed statistical significance (P < 0.05). There were statistically significant differences in PaO2, PaCO2, OI, and RI between two groups at 12, 24 and 48 h after ventilation (P < 0.05). After 72 h ventilation, there were significant differences in OI and RI between two groups (P < 0.05). The complication rate of study group was lower than that of control group, and the difference was statistically significant (P < 0.05). Conclusion HFOV combined with calf pulmonary surfactant in the treatment of neonatal ARDS can significantly improve the blood oxygen status, shorten the mechanical ventilation and oxygen use time, and reduce the incidence of complications, which has good clinical efficacy.
李杰 张荷花 李磊 李帅▲. 高频震荡通气联合牛肺表面活性剂治疗新生儿急性呼吸窘迫综合征的临床效果[J]. 中国医药导报, 2022, 19(26): 103-106.
LI Jie ZHANG Hehua LI Lei LI Shuai▲. Clinical effect of high frequency oscillatory ventilation combined with calf pulmonary surfactant in the treatment of neonatal with acute respiratory distress syndrome. 中国医药导报, 2022, 19(26): 103-106.
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