Exploring Professor Huang Li’s experience in treating different types of essential hypertension based on data mining
REN Weiquan1 ZHANG Gaoyu2 LIAO Jiangquan3 YAO Ruiqi2 HUANG Li3▲
1.Department of Traditional Chinese Medicine, Xuanwu Hospital Capital Medical University, Beijing 100053, China;
2.Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;
3.National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China
Abstract：Objective To analyze the medical case prescriptions of Professor Huang Li for the treatment of essential hypertension, and to summarize the relevant medication rules of Professor Huang Li for the treatment of essential hypertension. Methods The 597 prescriptions written by Professor Huang Li at China-Japan Friendship Hospital from January 2014 to December 2019 were collected, and frequency analysis, cluster analysis, and association rule analysis were performed to observe the distribution of their patient evidence types and core drug combinations. Results The 597 prescriptions included in the analysis were counted according to the evidence of liver-yang hyperactivity, qi deficiency and blood stasis, wind-phlegm upheaval, yin deficiency and fire stasis, and blood stasis, among which 365 patients (60.93%) with liver-yang hyperactivity syndrome, 79 patients (13.19%) with wind-phlegm upheaval syndrome, 72 patients (12.02%) with yin deficiency and fire stasis syndrome, 47 patients (7.85%) with qi deficiency and blood stasis syndrome, 34 patients (5.68%) with blood stasis syndrome. Cluster analysis and association rule analysis showed that the core Chinese medicine combination of liver-yang hyperactivity syndrome was Puerariae Lobatae Radix-Uncariae Ramulus cum Uncis-Chuanxiong Rhizoma-Gastrodiae Rhizoma. The core Chinese medicine combination of wind-phlegm syndrome was Atractylodis- Macrocephalae Rhizoma-Rhodiola rosea-Semen Platycladi. The core Chinese medicine combination of yin deficiency and fire was Taxilli Herba-Paeoniae Radix Rubra. The core Chinese medicine combination of qi deficiency and blood stasis syndrome was Chuanxiong Rhizoma - Notoginseng Radix. The core Chinese medicine combination of stasis block syndrome was Macrocephalae Rhizoma-Croci Stigma-Astragali Radix-Notoginseng Radix. Cluster analysis showed that the syndrome of liver-yang hyperactivity, qi deficiency and blood stasis, wind-phlegm upheaval, yin deficiency and fire stasis and blood stasis were clustered into 5, 5, 4, 5, and 4 categories respectively. Conclusion Professor Huang Li’s clinical treatment of primary hypertension commonly used to pacify the liver and calming the wind, invigorating blood stasis and calming the mind, paying attention to the important role of the liver in the pathogenesis of hypertension and pathological factors such as blood stasis, and using targeted drug combinations.
任卫全1 张高钰2 廖江铨3 姚睿祺2 黄力3▲. 基于数据挖掘探讨黄力教授治疗不同证型原发性高血压的用药经验[J]. 中国医药导报, 2023, 20(10): 7-12.
REN Weiquan1 ZHANG Gaoyu2 LIAO Jiangquan3 YAO Ruiqi2 HUANG Li3▲. Exploring Professor Huang Li’s experience in treating different types of essential hypertension based on data mining. 中国医药导报, 2023, 20(10): 7-12.
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