鸡蛋组分蛋白、半乳糖凝集素-3与过敏原IgE抗体联合检测在鸡蛋过敏患儿诊断中的价值

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摘要目的探讨鸡蛋组分蛋白、半乳糖凝集素-3与过敏原IgE抗体联合检测在鸡蛋过敏患儿诊断中的价值。方法选择2017年2月~2018年4月在四川大学华西广安医院进行过敏反应筛查的47例食物过敏患者作为研究组，另选择同期就诊的20例无过敏史，且静脉抽血化验、鸡蛋血清特异性IgE结果为阴性者作为对照组。对两组研究对象血清鸡蛋组分蛋白、半乳糖凝集素-3与过敏原IgE抗体进行检测。结果根据后期随访，研究组47例疑似鸡蛋过敏患儿中有42例为鸡蛋过敏患儿，其他为误诊。研究组sIgE、总IgE水平均高于对照组，差异有统计学意义（P < 0.05）。研究组食入物IgE阳性率为91.49%，吸入物阳性率为82.98%，食入物与吸入物IgE双阳性率为70.21%。研究组患儿卵白蛋白、卵类黏蛋白、卵转铁蛋白、溶菌酶OD值均显著低于对照组，差异有统计学意义（P < 0.05），且对照组OD值接近空白孔。研究组患儿半乳糖凝集素-3水平显著高于对照组，差异有统计学意义（P < 0.05）。鸡蛋组分蛋白对鸡蛋过敏患儿诊断的灵敏度、准确性、特异性分别为0.905、0.872、0.601。过敏原IgE对鸡蛋过敏患儿诊断的灵敏度、准确性、特异性分别为0.929、0.894、0.600，联合检测对鸡蛋过敏患儿诊断的灵敏度、准确性和特异性分别为0.976、0.957、0.831。结论鸡蛋组分蛋白、半乳糖凝集素-3与过敏原IgE抗体联合检测对鸡蛋过敏患儿诊断的灵敏度、准确性、特异性均较高，具有较高的临床应用价值。

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	唐川婷

关键词 ：鸡蛋组分蛋白, 半乳糖凝集素-3, 过敏原IgE, 抗体, 联合检测, 鸡蛋过敏, 诊断价值

Abstract：Objective To investigate the value of combined detection of egg component protein, galactose agglutinin-3 and allergen IgE antibody in the diagnosis of egg allergy. Methods Forty-seven patients with food allergy who were screened in West China-Guang′an Hospital, Sichuan University from February 2017 to April 2018 were selected as study group. Another 20 patients without allergie history and negative results venous blood test and egg serum-specific IgE were selected as the control group. Serum egg component protein, galactose agglutinin-3 and allergen IgE antibody were detected in two groups. Results According to anaphase follow-up, there were 42 cases of egg allergy and the others were misdiagnosed in 47 suspected children with egg allergy. The levels of sIgE and total IgE in the study group were higher than those in the control group, the differences were statistically significant (P < 0.05). In the study group, the positive rates of IgE and inhales were 91.49% and 82.98%, respectively. The positive rates of ingestion and inhaled IgE were 70.21%. The OD values of ovalbumin, ovomucoid, otransferrin and lysozyme in the study group were significantly lower than those in the control group, the differences were statistically significant (P < 0.05), and the OD value of the control group was close to the blank hole. The level of galactose agglutinin-3 in the study group was significantly higher than that in the control group, the difference was statistically significant (P < 0.05). The sensitivity, accuracy and specificity of egg component protein in the diagnosis of children with egg allergy were 0.905, 0.872, 0.601, respectively. The sensitivity, accuracy and specificity of allergen IgE in the diagnosis of children with egg allergy were 0.929, 0.894, 0.600, respectively. The sensitivity, accuracy and specificity of combined detection of egg allergy were 0.976, 0.957, 0.831, respectively. Conclusion The combined detection of egg component protein, galactose agglutinin-3 and allergen IgE antibody is of high sensitivity, accuracy and specificity in the diagnosis of egg allergy, has high value in clinical application.

Key words： Egg component protein Galactose agglutinin-3 Allergen IgE Antibody Combined detection Egg allergy Diagnostic value

引用本文:

唐川婷. 鸡蛋组分蛋白、半乳糖凝集素-3与过敏原IgE抗体联合检测在鸡蛋过敏患儿诊断中的价值[J]. 中国医药导报, 2018, 15(32): 88-91.
TANG Chuanting. Diagnostic value of egg component protein, galactose agglutinin-3 and allergen IgE antibody applied in the diagnosis of children with egg allergy. 中国医药导报, 2018, 15(32): 88-91.

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