Relationship between peripheral blood circulating tumor cells and pathological parameters and prognosis of patients with renal cancer
LI Hao1 CHEN Congbo1 YAO Qisheng1 GONG Xiaofang2▲
1.Department of Urology, Taihe Hospital Affiliated Hospital of Hubei University of Medicine, Hubei Province, Shiyan 442000, China;
2.Department of Anesthesiology, Taihe Hospital Affiliated Hospital of Hubei University of Medicine, Hubei Province, Shiyan 442000, China
Abstract：Objective To explore the relationship between peripheral blood circulating tumor cells (CTCs) and pathological paramets, and prognosis of renal cancer. Methods One hundred and seven patients with renal cell carcinoma admitted to Taihe Hospital of Shiyan in Hubei Province, from February 2014 to December 2017 and 20 healthy volunteers who performed physical examination were enrolled in the study. The immunomagnetic enrichment and immunofluorescence staining methods were used to count peripheral blood CTCs. The relationship between the positive rate of CTCs and age, gender, clinical stage, T stage, Fuhrman grade, clinical parameters such as neutrophils, serum calcium and platelets were analyzed. The relationship between peripheral blood CTCs and the prognosis of renal cancer was explored. Results The detection rate of CTCs in patients with renal cancer was 66.35%. No CTCs were found in peripheral blood of healthy volunteers. The positive rate of CTCs was related to the T stage, clinical stage and increase of neutrophils (P ＜ 0.05). Logistic regression analysis showed that T stage was an independent risk factor (OR = 1.816, 95%CI: 0.814-4.052, P ＜ 0.05). All the patients were followed up for 60-627 d. The median survival time of CTCs positive patients was shorter than that of CTCs negative patients (P ＜ 0.05). Conclusion The positive rate of CTCs in peripheral blood is related to T stage, clinical stage and increase of neutrophils in patients with renal cancer. The T stage of tumor is an independent risk factor for peripheral blood CTCs. Peripheral blood CTCs can be used as auxiliary information for judging the prognosis of patients with renal cancer.
李昊1 陈从波1 姚启盛1 龚小芳2▲. 外周血循环肿瘤细胞与肾癌病理指标及患者预后的关系[J]. 中国医药导报, 2019, 16(2): 85-88.
LI Hao1 CHEN Congbo1 YAO Qisheng1 GONG Xiaofang2▲. Relationship between peripheral blood circulating tumor cells and pathological parameters and prognosis of patients with renal cancer. 中国医药导报, 2019, 16(2): 85-88.
[1] 付伟金，吴潇芸，吕佰豪，等.CanPatrol TM法检测肾癌患者循环肿瘤细胞的初步分析[J].广东医学，2016，37（17）：2606-2608.
[2] Bukowski RM，Negrier S，Elson P. Prognostic factors in patients with advanced renal cell carcinoma：development of an international kidney cancer working group [J]. Clin Cancer Res，2012，10（4）：262-270.
[3] Tan HJ，Norton EC，Ye Z，et al. Long-term Survival Following Partial vs. Radical Nephrectomy Among Older Patients With Early-Stage Kidney Cancer [J]. JAMA，2012， 307（15）：1629-1635.
[4] 吴润芝，张为群，王信成，等.TACE联合利卡汀治疗对肝癌患者病理指标及CTCs检出数的影响[J].中国现代医学杂志，2017，27（28）：29-35.
[5] Hupert ML，Jackson JM，Wang H，et al. Arrays of High-Aspect Ratio Microchannels for High-Throughput Isolation of Circulating Tumor Cells（CTCs）[J]. Microsyst Technol，2014，20（10/11）：1815.
[6] Gradilone A，Naso G，Raimondi C，et al. Circulating tumor cells（CTCs）in metastatic breast cancer（MBC）：prognosis，drug resistance and phenotypic characterization [J]. Ann Oncol，2011，22（1）：86-92.
[7] Heller G，Fizazi K，Mccormack RT，et al. The added value of circulating tumour cell enumeration to standard markers in assessing prognosis in a metastatic castration-resistant prostate cancer population [J]. Clin Cancer Res，2016，23（8）：1967-1973.
[8] Bhindi B，Karnes RJ，Rangel LJ，et al. Independent Validation of the American Joint Committee on Cancer 8th Edition Prostate Cancer Staging Classification [J]. J Urol，2017，198（6）：1286.
[9] Nakajima R，Nozaki S，Kondo T，et al. Evaluation of renal cell carcinoma histological subtype and fuhrman grade using 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography [J]. Eur Radiol，2017，6（11）：1-8.
[10] 刘涛，郭建极，周华富，等.食管鳞状细胞癌患者复发转移与外周血循环肿瘤细胞的关系[J].中华实验外科杂志，2017，34（2）：311-313.
[11] 李刚，宋华林，牛远杰.循环肿瘤细胞检测在前列腺癌诊治中的价值[J].中华泌尿外科杂志，2016，37（9）：715-717.
[12] 明星，胡荍，谢多双，等.食管鳞癌循环肿瘤细胞在新辅助放化疗中动态变化及预后意义[J].中华肿瘤防治杂志，2017，24（8）：561-565.
[13] Giuliano M，Giordano A，Jackson S，et al. Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination [J]. Breast Cancer Res，2014，16（5）：440.
[14] Tol J，Koopman M，Miller MC，et al. Circulating tumour cells early predict progression-free and overall survival in advanced colorectal cancer patients treated with chemotherapy and targeted agents [J]. Ann Oncol，2010， 21（5）：1006.
[15] 张浩强，李明辉，王臻，等.免疫荧光联合原位杂交技术检测骨肉瘤患者外周血中循环肿瘤细胞的表达及临床意义[J].中华肿瘤杂志，2017，39（7）：11-13.
[16] Suzuki T，Sadahiro S，Tanaka A，et al. A Modified Classification of Prognostic Factors Based on Pathological Stage and Tumor Regression Grade in Patients with Rectal Cancer Who Receive Preoperative Chemoradiotherapy [J]. Oncology，2017，338（5）：202.
[17] Zhu L，Mei J，Liu C，et al. T-stage and range of resection of non-small cell lung cancer with directly invasion of the adjacent lobe [J]. Eur J Cardiothorac Surg，2017，7（9）：112-114.
[18] 罗斌，田建辉，刘嘉湘.循环肿瘤细胞免疫逃逸的研究进展[J].中华肿瘤防治杂志，2015，22（23）：1856-1860.
[19] Eruslanov E，Bhojnagarwala P，Quatromoni J，et al. The origin and role of APC-like hybrid tumor-associated neutrophils in early-stage human lung cancer [J]. Cancer Cell，2016，76（15 Supplement）：A02.
[20] Bluemke K，Bilkenroth U，Meye A，et al. Detection of circulating tumor cells in peripheral blood of patients with renal cell carcinoma correlates with prognosis [J]. Cancer Epidemiol Biomarkers Prev，2009，18（8）：2190-2194.
2019, Vol. 16 
京公网安备 11010502046598号