1.Department of Pediatrics, General Hospital of Fuxin Mining Industry (Group) Company with Limited Liability, Liaoning Province, Fuxin 123000, Chian;
2.Department of General Surgery, Xi′an Central Hospital, Shaanxi Province, Xi′an 710003, China;
3.Department of Neonatal, Second Affiliated Hospital of Xi′an Jiao Tong University, Shaanxi Province, Xi′an 710003, China
Abstract：Objective To study the relationship between erythrocyte immunity, level of serum inflammatory factors and the degree of dehydration in children with rotavirus enteritis. Methods From February 2015 to February 2018, in General Hospital of Fuxin Mining Industry (Group) Company with Limited Liability, the clinical data of 82 children with rotavirus enteritis were retrospectively analyzed, according to the degree of dehydration, they were divided into mild dehydration group (25 cases), moderate dehydration group (27 cases), and severe dehydration group (30 cases), another 30 healthy children had physical examination were selected as control group. The level of erythrocyte immune indexes and serum inflammatory factors in each group was compared, and correlation analysis was made. Results The level of immune adherence enhance factor (RFER), enhancing rosette rate of phygocytosis of red cells on neutrophils (ERPN) and erythrocyte C3b receptor rosette rate (RBC-C3bR) in the control group, mild dehydration group, moderate dehydration group and severe dehydration group decreased gradually, the level of immune adherence inhibitor factor (RFIR) and immunocomplex receptor chaplet rate (RBC-ICR) increased gradually, the differences were statistically significant (P < 0.05). The level of tumor necrosis factor-α (TNF-α), procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in the control group, mild dehydration group, moderate dehydration group and severe dehydration group increased gradually, the differences were statistically significant (P < 0.05). Spearman correlation analysis showed that TNF-α, PCT, hs-CRP were negatively correlated with RFER, ERPN, RBC-C3bR (P < 0.05), they were positively correlated with FEIR and RBC-ICR (P < 0.05). Conclusion The level of erythrocyte immunity and serum inflammatory factors are closely related to the degree of dehydration in children with rotavirus enteritis, it can provide basis for disease diagnosis and severity assessment of children with rotavirus enteritis.
2019, Vol. 16 
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