Influence of prophylactic oophorectomy on hormone level and life quality of postmenopausal women
CONG Fenghui1 LI Xiaodong2▲ LIU Jia3
1.Dalian Municipal Women and Children's Medical Center, Liaoning Province, Dalian 116001, China; 2.Cancer Stem Cell Research Institute, Dalian Medical University, Liaoning Province, Dalian 116044, China; 3.Department of Obstetrics and Gynecology, Liaoning Cancer Hospital, Liaoning Province, Shenyang 110042, China
Abstract：[Abstract] Objective To explore the change of hormone levels of the postmenopausal women after prophylactic oophorectomy. Methods From December 2010 to March 2011, 29 patients with benign uterine lesions and given prophylactic bilateral ovaries line excision in Dalian Maternity Hospital were selected as the research objects, and all of the patients were postmenopausal women. According to duration of menopause, they were divided into three groups: group A (1-3 years), 9 cases; group B (> 3-10 years), 10 cases; group C (> 10 years), 10 cases. Kupperman scoring was used to evaluate the feel of patients in three groups before and after surgery; the follicle-stimulating hormone (FSH), estrogen (E2) and testosterone levels at preoperative, 3 months postoperative and 12 months postoperative of patients in three groups were tested and compared. Results 3 months postoperative, the total Kupperman scores of group A and B were significantly higher than that of preoperative (P < 0.05); scores of hot and sweating, heart palpitations, fatigue and urinary tract disease of patients in group C before and after surgery had statistically significant differences (P < 0.05); before operation, score of heart palpitations between group C and group A had statistically significant differences (P < 0.05), urinary tract symptoms between group C and group B had statistically significant differences (P < 0.05). 3 months postoperative levels of E2, FSH and testosterone of patients in group A were obviously decreased than those before operation (P < 0.05), levels of E2 and testosterone of patients in group B were obviously decreased than those before operation (P < 0.05), and 12 months postoperative risen again; FSH showed opposite change tendency, higher at 3 months postoperative, fall at 12 months postoperative, but was also higher than preoperative (P < 0.05). Conclusion Menopause patients especially patients with duration of menopause less than 3 years, within 3 years androgen and estrogen will significantly decrease after preventive ovaries remove, and increases FSH significantly, aggravate the menopausal symptoms, and lower the quality of life.
丛丰辉1 李晓东2▲ 刘 佳3. 预防性卵巢切除术对绝经后妇女激素水平及生活质量的影响[J]. 中国医药导报, 2016, 13(3): 98-101.
CONG Fenghui1 LI Xiaodong2▲ LIU Jia3. Influence of prophylactic oophorectomy on hormone level and life quality of postmenopausal women. 中国医药导报, 2016, 13(3): 98-101.
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