抑郁症患者血清脑源性神经生长因子、P物质、白细胞介素-6水平变化及临床意义

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摘要目的研究抑郁症患者血清脑源性神经生长因子（BDNF）、P物质（SP）、白细胞介素-6（IL-6）水平变化情况，并分析其临床意义。方法以2016年3月～2018年3月浙江省衢州市第三医院收治的60例抑郁症患者为抑郁症组，根据病情严重程度将其分为轻度组（n = 15）、中度组（n = 29）、重度组（n = 16）；根据病程分为病程＜5年（n = 28），病程≥5年（n = 32）。另取同期60名健康体检人员为健康对照组。检测并比较各组血清BDNF、SP、IL-6水平，并分析患者血清BDNF、SP、IL-6水平之间的相关性。结果抑郁症组患者血清BDNF水平低于健康对照组，而SP、IL-6水平高于健康对照组，差异有统计学意义（P ＜ 0.05）。轻度组、中度组、重度组血清BDNF水平呈逐渐降低趋势，而血清SP、IL-6水平呈逐渐升高趋势，组间总体比较差异有统计学意义（P ＜ 0.05）。病程＜5年抑郁症患者血清BDNF水平高于病程≥5年患者，而血清SP、IL-6水平低于病程≥5年患者，差异有统计学意义（P ＜ 0.05）。经Pearson相关性分析可得：抑郁症患者血清BDNF与SP、IL-6均呈负相关（r = -0.632、-0.601，均P ＜ 0.05），而SP与IL-6呈正相关（r = 0.676，P ＜ 0.05）。结论抑郁症患者血清BNDF水平显著降低，而SP、IL-6水平升高，三项指标水平均与抑郁症患者病情严重程度以及病程相关。

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	王梅1 程韬2 杨开仁1 金庞1 周波1

关键词 ：抑郁症, 脑源性神经生长因子, P物质, 白细胞介素-6, 相关性

Abstract：Objective To study the changes of serum brain-derived neurotrophic factor (BDNF), substance P (SP) and interleukin-6 (IL-6) levels in patients with depression and to analyze their clinical significance. Methods Sixty cases of patients with depression admitted to the Third Hospital of Quzhou City from March 2016 to March 2018 were recorded as the depression group, according to the severity of illness, they were divided into mild group (n = 15), moderate group (n = 29) and severe group (n = 16), and divided into duration of disease ＜5 years (n = 28) and duration of disease ≥5 years (n = 32) according to the course of disease. Another 60 healthy persons who took physical examination at the same time were recorded as healthy control group. The levels of serum BDNF, SP and IL-6 in the two groups were compared respectively, and the relationship between the level of serum BDNF, SP and IL-6 in patients was analyzed. Results The level of serum BDNF of patients in the depression group was lower than that in the healthy control group, while the levels of SP and IL-6 were higher than the healthy control group, the differences were statistically significant (P ＜ 0.05). The levels of serum BDNF in mild group, moderate group and severe group decreased gradually, while the levels of serum SP and IL-6 increased gradually, the differences were statistically significant among the there groups (P ＜ 0.05). The level of serum BDNF in patients with depression ＜5 years was higher than that in patients with depression ≥5 years, while serum SP and IL-6 levels in patients with depression ＜5 years were lower than those in patients with depression ≥5 years, the differences were statistically significant (P ＜ 0.05). Pearson correlation analysis showed that serum BDNF was negatively correlated with SP and IL-6 (r = -0.632, -0.601, all P ＜ 0.05), while SP was positively correlated with IL-6 (r = 0.676, P ＜ 0.05). Conclusion The level of serum BDNF of patients with depression is significantly decreased, while the levels of SP and IL-6 are increased. The levels of these three indexes are related to the severity and course of depression.

Key words： Depression Brain-derived neurotrophic factor Substance P Interleukin-6 Correlation

基金资助:浙江省医药卫生科技计划项目（2016ZHB040）。

引用本文:

王梅1 程韬2 杨开仁1 金庞1 周波1. 抑郁症患者血清脑源性神经生长因子、P物质、白细胞介素-6水平变化及临床意义[J]. 中国医药导报, 2019, 16(13): 95-98.
WANG Mei1 CHENG Tao2 YANG Kairen1 JIN Pang1 ZHOU Bo1. Changes and clinical significance of serum levels of brain-derived neurotrophic factor, substance P and interleukin-6 in patients with depression. 中国医药导报, 2019, 16(13): 95-98.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I13/95

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