Relationship between serum chemerin level and epicardial adipose tissue volume and coronary artery calcification in maintenance hemodialysis patients
LI Xiuyong1 WANG Li2 MA Tao1
1.Blood purification center, NO.2 People′s Hospital of Fuyang City, Anhui Province, Fuyang 236000, China;
2.Department of nephrology, Shenzhen Longhua District People′s Hospital, Guangdong Province, Shenzhen 518109, China
Abstract：Objective To study the relationship between serum chemerin and epicardial adipose tissue volume, coronary artery calcification in maintenance hemodialysis patients. Methods From February 2015 to February 2018, 96 patients with maintenance hemodialysis admitted to NO.2 People′s Hospital of Fuyang City were selected as the study group. Another 50 healthy persons who received physical examination in the same period were recorded as control group. The levels of biochemical indexes in the two groups were compared. At the same time, the study group was divided into low-risk group (50 cases), medium-risk group (27 cases) and high-risk group (19 cases) according to Framingham risk score. The volume of epicardial adipose tissue, coronary artery calcification score and serum chemerin level in the three groups were compared, and the correlation analysis was made. Results The levels of chemerin, neutrophil percentage, neutrophils/lymphocytes, C-reactive protein, urea, creatinine, fasting blood glucose in the study group were higher than those in the control group, the platelet count was lower than that in the control group, the differences were highly statistically significant (P < 0.01). The volume of epicardial adipose tissue, coronary artery calcification score and serum chemerin level in low-risk group, medium-risk group and high-risk group showed a gradual increase trend, the differences were highly statistically significant (P < 0.01). The serum chemerin level of maintenance hemodialysis patients was positively correlated with the volume of epicardial adipose tissue and coronary artery calcification score (r = 0.713, 0.689, P < 0.05). Conclusion The elevation of serum chemerin in maintenance hemodialysis patients is closely related to epicardial adipose tissue and coronary artery calcification. Detection of serum chemerin can predict the risk of cardiovascular disease in patients.
2019, Vol. 16 
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