Abstract：Objective To investigate the effect of Ginseng combined with Taohong Siwu Decoction on cardiac function and blood lipid in patients with coronary heart disease and angina pectoris. Methods One hundred and one patients with coronary heart disease and angina pectoris admitted to Baiyun Branch of Guangdong Second Hospital of Traditional Chinese Medicine from September 2015 to June 2018 were selected. The patients were divided into control group (50 cases) and study group (51 cases) according to the random number table method. The control group was treated with routine comprehensive treatment, while the study group was treated with Ginseng combined with Taohong Siwu Decoction on the basiss of the control group. The changes of clinical efficacy, cardiac function index and blood lipid index were compared between the two groups, and the adverse reactions during treatment were observed. Results The total effective rate of the study group was 94.12% after treatment, which was significantly higher than that in the control group (74.00%), and the difference was statistically significant (P ＜ 0.05). After treatment, the left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) of the study group were significantly lower than that of the control group, and the left ventricular ejection fraction (LVEF) was significantly higher than that of the control group, and the differences were statistically significant (P ＜ 0.05). Compared with before treatment, LVESD and LVEDD were significantly decreased and LVEF was significantly increased in the two groups after treatment, and the differences were statistically significant (P ＜ 0.05). After treatment, the triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in the study group were lower than those in the control group, and high density lipoprotein cholesterol (HDL-C) was significantly higher than that in the control group, the differences were statistically significant (P ＜ 0.05). Compared with before treatment, TG, TC and LDL-C were significantly decreased in both groups, and HDL-C was significantly increased, the differences were statistically significant (P ＜ 0.05). There was no significant difference in adverse reactions between the two groups during treatment (P ＞ 0.05). Conclusion Ginseng combined with Taohong Siwu Decoction in the treatment of patients with coronary heart disease and angina pectoris has a definite curative effect, which can effectively improve the cardiac function and blood lipid status of patients without increasing the incidence of adverse reactions. It has certain clinical application value.
陈建昊 王金良 曾明珠. 人参合桃红四物汤对冠心病心绞痛患者心功能及血脂的影响[J]. 中国医药导报, 2019, 16(24): 135-138.
CHEN Jianhao WANG Jinliang ZENG Mingzhu . Effect of Ginseng combined with Taohong Siwu Decoction on cardiac function and blood lipid in patients with coronary heart disease and angina pectoris. 中国医药导报, 2019, 16(24): 135-138.
[1] 陈慧敏，许逸飞.曲美他嗪联合阿托伐他汀钙治疗冠心病心绞痛伴血脂异常的临床研究[J].中国临床药理学杂志，2016，32（11）：966-968.
[2] Fan Y，Gu X，Zhang H. Dazhu Hongjingtian（Herba Rhodiolae）for unstable angina pectoris：Protocol for a systematic review and meta-analysis [J]. Medicine（Baltimore），2018， 97（49）：e13481.
[3] Park SH，Choi BG，Rha SW，et al. The multi-vessel and diffuse coronary spasm is a risk factor for persistent angina in patients received anti-angina medication [J]. Medicine（Baltimore），2018，97（47）：e13288.
[4] 马维军，王海燕.通心络联合氯吡格雷治疗对冠心病心绞痛临床症状及血流动力学的影响[J].中国老年学杂志，2015，35（5）：1197-1199.
[5] Sikora J，Niezgoda P，Barańska M，et al. METOclopramide Administration as a Strategy to Overcome MORPHine-ticagrelOR Interaction in PatientS with Unstable Angina PectorIS-The METAMORPHOSIS Trial [J]. Thromb Haemost，2018，118（12）：2126-2133.
[6] 谭昕，太加斌，方袁媛，等.麝香保心丸治疗冠心病心绞痛及对患者血清炎症因子的影响[J].中国老年学杂志，2016，36（2）：316-318.
[7] 毛华晋，凃刚城，邱静，等.桃红四物汤对股骨干骨折术后炎性因子和血液流变学的影响[J].南京中医药大学学报，2016，32（5）：419-421，497.
[8] 陈灏珠，林果为.实用内科学[M].13版.北京：人民卫生出版社，2009.
[9] 郑筱萸.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002.
[10] Sincer I，Gunes Y，Mansiroglu AK，et al. Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease [J]. Postepy Kardiol Interwencyjnej，2018，14（3）：263-269.
[11] 何云，成小凤，范华平，等.反应性充血指数对冠心病患者PCI术后心绞痛的预测价值[J].重庆医学，2017，46（10）：1315-1318，1322.
[12] Qian H，Luo Z，Xiao C，et al. Red cell distribution width in coronary heart disease：prediction of restenosis and its relationship with inflammatory markers and lipids [J]. Postgrad Med J，2018，94（1115）：489-494.
[13] 张志芳，左建华，肖华， 等.栝楼薤白半夏汤加味结合西医常规疗法治疗气滞血瘀型冠心病心绞痛 临床研究[J].国际中医中药杂志，2016，38（12）：1076-1079.
[14] 何训，吕世文，郭佳奕，等.丹参多酚酸盐治疗冠心病的临床疗效及安全性[J].中国临床药理学杂志，2016，23（2）：105-107.
[15] 祁德波，梁振湖.桃红四物汤加减口服对骨科围手术期气滞血瘀证患者血液流变学及凝血指标的影响[J].中国中医急症，2015，24（8）：1485-1486.
[16] 沈安鲁，彭代银，施慧，等.桃红四物汤保护2型糖尿病模型大鼠血管损伤的实验研究[J].安徽中医药大学学报，2018，37（3）：67-70.
[17] 赵小华.加味桃红四物汤治疗湿热瘀结型慢性盆腔炎并盆腔痛57例[J].中国药业，2015，24（14）：110-112.
[18] 金成鹏，孙绍裘，彭志飞，等.桃红四物汤对大鼠血管吻合模型吻合区Delta-like4表达及血管新生的影响[J].中医正骨，2017，29（12）：1-5.
[19] 刘彤杉，周志春.桃红四物汤加减辅助治疗药物流产阴道出血临床观察[J].西部中医药，2015，28（1）：72-74.
[20] 曹舜，丁洪伟.疏血通注射液联合加味桃红四物汤预防老年骨质疏松压缩性骨折PKP术后静脉血栓的疗效及对D-二聚体的影响[J].中国中医急症，2018，27（7）：1147-1150.
[21] 刘发文.桃红四物汤加减治疗失代偿期肝硬化的疗效及对凝血功能的影响[J].现代中西医结合杂志，2016，25（15）：1662-1664.
[22] 欧妍.艾灸配合桃红四物汤对痛经患者血清ET-1、NO的影响[J].长春中医药大学学报，2015，31（3）：582-584.
[23] 许柳青.桃红四物汤对损伤瘀血模型大鼠血管内皮舒缩因子和血流变的影响[D].济南：山东中医药大学，2011.
[24] 甘程.加味桃红四物汤治疗冠心病稳定型心绞痛并血脂异常的临床疗效观察[D].南宁：广西中医药大学，2014.
2019, Vol. 16 
京公网安备 11010502046598号