Abstract：[Abstract] Objective To observe the clinical effect of oral Sanjie Ⅰ Prescription combined with local application of qi goiter acupoint in the treatment of benign thyroid nodules. Methods Eighty patients with benign thyroid nodules admitted to Zengcheng Hospital of Traditional Chinese Medicine in Guangzhou City from July 2014 to July 2015 were selected and randomly divided into two groups. 40 cases of the treatment group were taken oral Chinese medicine Sanjie Ⅰ Prescription combined with local application of Sanjie Ⅱ Prescription on bilateral qi goiter acupoint; 40 cases of the control group were taken oral Levothyroxine Tablets. The effects of two groups after treatment, the levels of thyroid hormones [thyroid stimulating hormone (TSH), serum free three iodine thyroid gland (FT3) and serum free thyroid hormone (FT4)] before and after treatment, the changes of the size of thyroid nodules and the changes of blood flow imaging in the nodules were observed. Results The total effective rate of treatment group was 92.5%, which of control group was 47.5%, the difference between the two groups was statistically significant (P ＜ 0.05). B ultrasound showed that the maximum diameter of the nodules [(9.23±4.52) mm] and the maximum cross-sectional area of the nodules [(65.53±55.42) mm2] were significantly decreased compared with the maximum diameter of the nodules [(12.36±4.68) mm] and the maximum cross section area [(75.66±52.08) mm2] of the control group, the differences were statistically significant (P ＜ 0.05). The levels of thyroid hormone (TSH, FT3, FT4) in the treatment group had no statistically significant differences compared with those before treatment (P ＞ 0.05). In the control group, the level of TSH after treatment [(0.73±0.34) mU/L] was decreased significantly compared with that before treatment [(1.96±0.79) mU/L] (P ＜ 0.05), the levels of FT3 [(3.95±2.33) pmol/L], FT4 [(13.95±2.61) pmol/L] after treatment were significantly increased compared with those before treatment [FT3: (3.52±1.06) pmol/L, FT4: (13.49±3.65) pmol/L] (P ＜ 0.05). There was a significant difference of blood flow classification after treatment between the two groups (P ＜ 0.05). Conclusion Oral medicinal herbs combined with external application of qi goiter acupoint in the treatment of benign thyroid nodules has a good effect, which is worthy of clinical promotion and application.
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