Abstract：This study reviews and discusses the biological functions of neuroglobin and the neuroprotective effects of neuroglobin in epilepsy and its specific mechanisms. Neuroglobin is mainly involved in the proliferation of neural stem cells, promoting axonal regeneration and reducing oxidative stress levels, regulating apoptosis and autophagy pathways, thereby alleviating acute neuronal damage. The specific mechanism of neuroprotection of neuroglobin in epilepsy is regulating the Pik3k/Akt signaling pathway, the Jak2/Stat3 pathway, and the inhibition of activation of caspase-3 activity, and cooperating with the erythropoietin receptor to initiate the relevant signal transduction pathway. This review provides new ideas for preventing the death of neuronal cells caused by epilepsy and reference for treating brain damage caused by epilepsy.
杜欢1 弥曼2 郭向阳3 刘曼玲2 刘娜3. 脑红蛋白在癫痫中的神经保护作用及其机制研究进展[J]. 中国医药导报, 2019, 16(28): 67-70.
DU Huan1 MI Man2 GUO Xiangyang3 LIU Manling2 LIU Na3. Updates on neuroprotective effects and mechanisms of neuroglobin in epilepsy. 中国医药导报, 2019, 16(28): 67-70.
[1] Burmester T，Weich B，Reinhardt S，et al. A vertebrate globin expressed in the brain [J]. Nature，2000，407（6803）：520-523.
[2] Lifton RP，Goldberg ML，Karp RW，et al. The Organization of the Histone Genes in Drosophila melanogaster： Functional and Evolutionary Implications [J]. Cold Spring Harb Symp Quant Biol，1978，42（2）：1047-1051.
[3] Yi L，Ling F，Xue XH，et al. Association between Ngb polymorphisms and ischemic stroke in the Southern Chinese Han population [J]. BMC Med Genet，2008，9（1）：110-120.
[4] Ascenzi P，di Masi A，Leboffe L，et al. Neuroglobin：From structure to function in health and disease [J]. Mol Aspects Med，2016，52：1-48.
[5] Cutrupi S，Ferrero G，Reineri S，et al. Genomic lens on neuroglobin transcription [J]. Iubmb Life，2014，66（1）：46-51.
[6] Elke F，Liesbet T，Wim M，et al. Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death [J]. Neurosci Lett，2006，410（2）：146-151.
[7] Lin Y，Cai B，Xue XH，et al. TAT-mediated delivery of neuroglobin attenuates apoptosis induced by oxygen-glucose deprivation via the Jak2/Stat3 pathway in vitro [J]. Neurol Res，2015，37（6）：531-538.
[8] 李直.乏氧应激与小鼠中枢神经系统脑红蛋白的表达[D].开封：河南大学，2017，6：1-50.
[9] Herold S，Fago A，Weber R E，et al. Reactivity studies of the Fe（Ⅲ）and Fe（Ⅱ）NO forms of human neuroglobin reveal a potential role against oxidative stress [J]. J Biol Chem，2004，279（22）：22841-22847.
[10] Luyckx E，Van LW，Andre D，et al. Loss of neuroglobin-expression alters Cdkn1a/Cdk6-expression resulting in increased proliferation of neural stem cells [J]. Stem Cells Dev，2018，27（6）：378-390.
[11] Xiong XX，Pan F，Chen RQ，et al. Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal [J]. Cell Death Dis，2018，9（2）：163-179.
[12] 高海浩，尚爱加，陶本章，等.氯化血红素诱导脊髓组织脑红蛋白高表达对脊髓损伤大鼠运动功能的保护作用[J].解放军医学院学报，2019，40（1）：58-61，67.
[13] Zhu L，Huang L，Wen Q，et al. Recombinant human erythropoietin offers neuroprotection through inducing endogenous erythropoietin receptor and neuroglobin in a neonatal rat model of periventricular white matter damage [J]. Neurosci Lett，2017，650：12-17.
[14] Gao Y，Mengana Y，Cruz YR，et al. Different Expression Patterns of Ngb and EPOR in the Cerebral Cortex and Hippocampus Revealed Distinctive Therapeutic Effects of Intranasal Delivery of Neuro-EPO for Ischemic Insults to the Gerbil Brain [J]. J Histochem Cytochem，2011，59（2）：214-227.
[15] 蔡瀚培，郑树法，康德智.脑红蛋白在中枢神经系统损伤中的保护作用研究进展[J].中华神经医学杂志，2018， 17（8）：847-850.
[16] 张菲菲，程艳伟，于敏敏，等.大鼠癫痫持续状态后海马组织各区脑红蛋白表达的实验研究[J].癫痫杂志，2017， 3（3）：217-222.
[17] 刘广韬，潘隆盛，尚爱加，等.惊厥发作不同时相下脑红蛋白表达的初步研究[J].山西医科大学学报，2013，44（4）：249-252，323.
[18] Dingledine R，Varvel NH，Dudek FE. When and how do seizures kill neurons，and is cell death relevant to epileptogenesis? [J]. Adv Exp Med Biol，2014，813：109-122.
[19] Rami A，Benz AP，Niquet J，et al. Axonal Accumulation of Lysosomal-Associated Membrane Protein 1（LAMP1）Accompanying Alterations of Autophagy Dynamics in the Rat Hippocampus Upon Seizure-Induced Injury [J]. Neurochem Res，2016，41（1/2）：53-56.
[20] Cabrera-López C，Martí T，Catalá V，et al. Assessing the effectiveness of rapamycin on angiomyolipoma in tuberous sclerosis： a two years trial [J]. Orphanet J Rare Dis，2012，7（1）：1-9.
[21] Li Q，Ying H，Du J，et al. Alterations of apoptosis and autophagy in developing brain of rats with epilepsy：Changes in LC3，P62，Beclin-1 and Bcl-2 levels [J]. Neurosci Res，2018，130：47-55.
[22] da Concei?觭ão RR，de Souza JS，de Oliveira KC，et al. Evaluation of neuroglobin and cytoglobin expression in adult rats exposed to silver nanoparticles during prepubescence [J]. Metab Brain Dis，2019，34（3）：705-713.
[23] Baez E，Echeverria V，Cabezas R，et al. Protection by Neuroglobin Expression in Brain Pathologies [J]. Front Neurol，2016，7：146-156.
[24] Emara M，Turner AR，Allalunisturner J，et al. Hypoxia differentially upregulates the expression of embryonic，fetal and adult hemoglobin in human glioblastoma cells [J]. Int J Oncol，2014，44（3）：950-958.
[25] Cai B，Li W，Mao X，et al. Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism [J]. Mol Neurobiol，2016，53（2）：1254-1265.
[26] Simon R. Neuroglobin：neuroprotection and neurogenesis [J]. Neurosci Lett，2013，549（33）：1-2.
[27] 张蓓，李亚军，张世俊，等.脑缺血后脑红蛋白的保护作用及信号转导机制[J].华中科技大学学报，2012，41（5）：566-568.
[28] Zhang B，Ji X，Zhang S，et al. Hemin mediated neuroglobin induction exerts neuroprotection following ischemic brain injury through PI3K/Akt signaling [J]. Mol Med Rep，2013，8（2）：681-685.
[29] Amri F，Ghouili I，Amri M，et al. Neuroglobin protects astroglial cells from hydrogen peroxide-induced oxidative stress and apoptotic cell death [J]. J Neurochem，2017， 140（1）：151-169.
2019, Vol. 16 
京公网安备 11010502046598号