Abstract：Objective To explore the importance of monitoring Voriconazole trough serum concentration (Cmin) in severe elderly patients. Methods From January 2014 to December 2018, a retrospective analysis was used to analyze 43 cases who admitted to the Third Affiliated Hospital of Anhui Medical University with severe elderly patients. All patients were treated with Voriconazole, monitored and observed for Cmin. The effects of different factors on the blood drug Cmin of Voriconazole and the clinical effects and adverse reactions of plasma albumin (ALB) on voriconazole were compared. Results The Cmin was tested 78 times and 54 times (69.2%) of Cmin was 1.0~5.5 mg/L. ALB and AST were independent risk factors for Cmin, and ALB was negatively correlated with Cmin (r = -0.903, P = 0.0003). AST was positively correlated with serum concentration (r = 0.872, P = 0.0005). The effective rate of ALB<35 g/L was lower than that of ALB≥35 g/L, and the incidence of adverse reactions was higher than that of ALB≥35 g/L, the differences were statistically significant (P < 0.05). Conclusion There are many factors that affect the concentration of voriconazole in the severe elderly patients. It is particularly necessary to monitor the concentration of Voriconazole in the blood.
2019, Vol. 16 
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