血清CyPA、Lp-PLA2水平与急性脑梗死患者病情的关系

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摘要目的探讨急性脑梗死患者血清亲环素A（CyPA）、脂蛋白相关性磷脂酶A2（Lp-PLA2）的水平及临床意义。方法收集2016年1月～2018年6月重庆市九龙坡区中医院（以下简称“我院）收治的117例急性脑梗死患者为病例组，根据神经功能缺损程度（NIHSS评分）将其分为轻型组（NIHSS＜7分，n = 51）、中型组（NIHSS 7～15分，n = 37）、重型组（NIHSS＞15分，n = 29），并选择同期我院60名健康体检者为对照组，采用酶联免疫吸附法测定各组血清CyPA、Lp-PLA2水平，颗粒免疫透射比浊法测定血清胱抑素C（CysC）、同型半胱氨酸（Hcy）、尿酸（UA）水平。结果病例组血清CyPA、Lp-PLA2水平高于对照组，且随着病情加重，血清CyPA、Lp-PLA2水平逐渐升高（P ＜ 0.05）。病例组血清CysC、Hcy、UA水平均高于对照组，且随着病情加重，血清CysC、Hcy、UA水平呈升高趋势（P ＜ 0.05）。Pearson积矩相关分析，病例组患者血清CyPA与Lp-PLA2呈正相关（r = 0.761，P ＜ 0.05），CyPA与CysC、Hcy、UA均呈正相关（r = 0.679、0.625、0.702，均P ＜ 0.05），Lp-PLA2与CysC、Hcy、UA均呈正相关（r = 0.738、0.711、0.692，均P ＜ 0.05）。结论血清CyPA、Lp-PLA2与急性脑梗死病情严重程度密切相关，早期检测对评估患者病情有临床价值。

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	伉奕1 马宇2 卢柳西2 展群岭2

关键词 ：急性脑梗死, 亲环素A, 脂蛋白相关性磷脂酶A2, 临床意义

Abstract：Objective To explore the levels and the clinical significant of serum cyclophilin A (CyPA), lipoprotein associated phospholipase A2 (Lp-PLA2) in patients with acute cerebral infarction. Methods A total of 117 patients with acute cerebral infarction admitted to Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from January 2016 to June 2018 were enrolled as case group, who were divided into slight group (NIHSS ＜7 scores, n = 51), moderate group (NIHSS 7-15 scores, n = 37), severe group (NIHSS ＞15 scores, n = 29) according to national institute of health stroke scale (NIHSS score). At the same time, 60 healthy examinees in our hospital were selected as control group. The serum CyPA and Lp-PLA2 of each groups were determined by enzyme-linked immunosorbent assay, and serum Cystatin C (CysC), homocysteine (Hcy) and uric acid (UA) were determined by granule immunoturbidimetry. Results The levels of serum CyPA and Lp-PLA2 in case group were higher than those in control group, and the levels of serum CyPA, Lp-PLA2 gradually increased with the condition worsened (P ＜ 0.05). The levels of serum CysC, Hcy, UA in case group were higher than those in control group, and the levels of serum CysC, Hcy, UA gradually increased with the condition worsened (P ＜ 0.05). Pearson product moment correlation analysis showed that serum CyPA was positive associated with Lp-PLA2 (r = 0.761, P ＜ 0.05). CyPA was positively correlated with CysC, Hcy and UA (r = 0.679, 0.625, 0.702, all P ＜ 0.05), Lp-PLA2 was positively correlated with CysC, Hcy and UA (r = 0.738, 0.711, 0.692, all P ＜ 0.05). Conclusion Serum CyPA and Lp-PLA2 are closely related to the severity of acute cerebral infarction. Early detection of CyPA and Lp-PLA2 has clinical value in evaluating patients′ condition.

Key words： Acute cerebral infarction Cyclophilin A Lipoprotein associated phospholipase A2 Clinical significance

基金资助:重庆市卫生计生委医学科研项目（2015HBRC011）；
重庆市南岸区卫生和计划生育委员会科研项目（2016-04）。

通讯作者: 展群岭（1963.9-），男，主任医师；研究方向：神经内科、脑血管疾病。

作者简介: 伉奕（1981.4-），女，副主任医师；研究方向：神经内科、脑血管疾病。

引用本文:

伉奕1 马宇2 卢柳西2 展群岭2. 血清CyPA、Lp-PLA2水平与急性脑梗死患者病情的关系[J]. 中国医药导报, 2019, 16(35): 123-126.
KANG Yi1 MA Yu2 LU Liuxi2 ZHAN Qunling2. Relationship between serum CyPA, Lp-PLA2 levels and disease status in patients with acute cerebral infarction. 中国医药导报, 2019, 16(35): 123-126.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I35/123

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