新生儿肠外营养相关性胆汁淤积的研究进展

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摘要随着肠外营养在新生儿中的广泛使用，肠外营养相关性胆汁淤积（PNAC）也成为新生儿特别是早产儿常见的并发症之一。该病常引起患儿肝细胞脂肪变性及胆汁淤积，进而形成胆汁性肝硬化，严重时可引起肝衰竭甚至死亡。因此该病应引起新生儿医师的高度重视。由于PNAC的发病机制尚不明确并存在许多争议，本文通过研究并总结大量近年来关于PNAC的文献，发现PNAC多与早产及低出生体重、长时间禁食、感染、肠外营养应用时间及营养比例失调、遗传等因素有关，本文将对其已知的发病机制、诊断、治疗及新的研究进展进行综述。

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	吕朦1 刘秀香1
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关键词 ：新生儿, 早产儿, 肠外营养相关性胆汁淤积, 肠外营养

Abstract：With the widespread use of parenteral nutrition in newborns, parenteral nutrition associated cholestasis (PNAC) has become one of the common complications in neonates, especially preterm infants. The disease often causes hepatocyte steatosis and cholestasis of the child, leads to biliary cirrhosis, which can cause liver failure and even death. Therefore, the disease should be highly valued by neonatal physicians. Due to the pathogenesis of PNAC is still unclear and controversial, this paper studys and summarizes a large number of recent literatures on PNAC, and found that PNAC is associated with premature birth and low birth weight, prolonged fasting, infection, parenteral nutrition application time, nutritional imbalance, and genetic factors. This article will review the known pathogenesis, diagnosis, treatment and new research progress.

Key words： Neonate Premature infant Parenteral nutritional associated cholestasis Parenteral nutrition

基金资助:国家卫生计生委医药卫生科技发展研究中心项目（W2015EAE078）。

通讯作者: 刘秀香（1975.4-），女，博士，主任医师；研究方向：早产儿及急危重症新生儿诊治。

作者简介: 吕朦（1988.5-），女，滨州医学院2017级儿科学专业在读硕士研究生；研究方向：早产儿及危重新生儿。

引用本文:

吕朦1 刘秀香1,2. 新生儿肠外营养相关性胆汁淤积的研究进展[J]. 中国医药导报, 2019, 16(36): 46-49.
LYU Meng1 LIU Xiuxiang1,2. Research progress on parenteral nutrition associated cholestasis in neonates. 中国医药导报, 2019, 16(36): 46-49.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I36/46

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