Discussion on application of ultrasonic multimodal combined technique in the evaluation of femoral rectus in rabbits with knee osteoarthritis
LIU Jing1 LIN Qiaoxuan2 GONG Yurong1 LIU Hong1,3 ZHANG Liangzhi1,3 XIU Zhongbiao1,3,4
1.The Second Department of Orthopedics and Traumatology, People′s Hospital Affiliated of Fujian University of Traditional Chinese Medicine, Fujian Province, Fuzhou 350004, China;
2.College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fujian Province, Fuzhou 350122, China;
3.Fujian Institute of Orthopaedics, Fujian Province, Fuzhou 350004, China;
4.Key Laboratory of Orthopedics & Traumatology and Rehabilitation of Traditional Chinese Medicine, Ministry of Education, Fujian Province, Fuzhou 350122, China
Abstract：Objective To provide a method and objective basis for the evaluation of chronic injury of skeletal muscles of knee osteoarthritis (KOA), the morphological, blood perfusion and tissue hardness changes of rectus femoris muscle in rabbits with KOA were observed by using ultrasound multimodal combined technique. Methods Sixteen New Zealand white rabbits were divided into the normal group and the model group by random number table method, with 8 rabbits in each group. The normal group was fed routinely. The modified Videman method was used to construct the KOA rabbit model in the model group. After 6 weeks of modeling, 2 cm above the iliac at the rectus femoris, the muscle pennation angle, muscle thickness, perimeter and cross-sectional area of KOA rabbit femoral rectus muscle were measured using a Philips EPIQ107 ultrasound machine to evaluate the morphology of rectus femoris; ACUSON S2000 ultrasound machine was used for imaging, and peak time and transit time were analyzed and compared to evaluate the perfusion of rectus femoris; Vivid E80 ultrasound machine was used for strain elastography, and elastic strain rate ratio of rectus femoris was measured to evaluate tissue hardness of rectus femoris. Results Compared with the normal group, muscle thickness, cross-sectional area, perimeter and pennation angle in the model group were significantly decreased, the ratio of ultrasonic elastic strain rate was significantly increased, and the peak time and transit time were significantly shortened in the model group, the differences were highly statistically significant (all P ＜ 0.01). Conclusion Ultrasonic multimodal combined technique, complements each other's advantages, it can objectively evaluate the condition of KOA rabbit femoral rectus muscle from the aspects of morphology, blood perfusion, and tissue hardness change, which is worthy of clinical application.
刘晶1 林巧璇2 宫玉榕1 刘洪1,3 张良志1,3 修忠标1,3,4. 超声多模态联合技术评估膝骨性关节炎兔股直肌病变的应用探析[J]. 中国医药导报, 2020, 17(7): 147-151.
LIU Jing1 LIN Qiaoxuan2 GONG Yurong1 LIU Hong1,3 ZHANG Liangzhi1,3 XIU Zhongbiao1,3,4. Discussion on application of ultrasonic multimodal combined technique in the evaluation of femoral rectus in rabbits with knee osteoarthritis. 中国医药导报, 2020, 17(7): 147-151.
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2020, Vol. 17 
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