Effects of Jiawei Tingli Dazao Xiefei Decoction combined with Urokinase in the treatment of encapsulated tuberculous pleurisy
XUE Jianhua1,2 CHENG Yang1,3 CHEN Jianjie1,3 MA Kang2 ZHOU Lin2 SHI Yahui2 WU Xiangxiang4
1.Department Infectious, Shanghai Pudong New Area Infectious Disease Hospital, Shanghai 201299, China;
2.Infectious Diseases Section, Xinjiang Shache People′s Hospital, Kashi Area of Xinjiang Uygur Autonomous Region, Xinjiang 844700, China;
3.Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 4.Department of Traditional Chinese Medicine, Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Abstract：Objective To observe the effect of modified Jiawei Tingli Dazao Xiefei Decoction combined with Urokinase in the treatment of wrapped tuberculous pleurisy. Methods A total of 46 patients with encapsulated tuberculous pleurisy in the Department of Infectious Diseases, Xinjiang Shache People′s Hospital, Xinjiang Uygur Autonomous Region from August 2018 to June 2019 were selected. According to the random number table method, they were divided into the treatment group (32 cases) and the control group (23 cases). The control group received chest drainage and Urokinase injection and 2HRZE/7HRE antituberculosis treatment based on a standardized antituberculosis regimen, and on this basis, the treatment group was treated with Jiawei Tingli Dazao Xiefei Decoction. The course of treatment was 1 week, followed by standard anti-tuberculosis treatment. After the course of treatment, the disappearance time of pleural effusion, pleural thickness, B-ultrasonic effusion depth, length of hospital stay and traditional Chinese medicine syndrome score of the two groups were observed. Results After treatment, the effusion disappearance time in the treatment group was shorter than that in the control group, and the difference was statistically significant (P ＜ 0.05); the depth of effusion measured by B-ultrasound in the treatment group was significantly lower than that in the control group, and the difference was highly statistically significant (P ＜ 0.01); The pleural thickness of the treatment group was significantly lower than that of the control group, and the difference was highly statistically significant (P ＜ 0.01); the length of hospital stay in the treatment group was shorterer than that of the control group, and the difference was statistically significant (P ＜ 0.05). The scores of various traditional Chinese medicine symptoms in the two groups were lower after treatment than before treatment, and the scores of fever, cough, sputum and chest pain in the treatment group were lower than those in the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in the scores of hemoptysis and shortness of breath between the two groups after treatment (P ＞ 0.05). Patients of the two groups had not obvious bleeding, pain, itching and other adverse reactions. Conclusion Jiawei Tingli Dazao Xiefei Decoction can improve the absorption of pleural effusion, improve the degree of pleural thickening, shorten the length of hospital stay and improve the symptoms of traditional Chinese medicine.
2020, Vol. 17 
京公网安备 11010502046598号