Research progress of Panax quinquefolium L. therapy for ischemic heart disease
LIU Yansong1 WANG Di1 HAO Zhenzhu1 GUO Huiwen1 PIAO Xinghu1 FANG Meishan2 WANG Bingmei1
1.School of Basic Medicine, Changchun University of Traditional Chinese Medicine, Jilin Province, Changchun 130117, China;
2.Department of Traditional Chinese Medicine, China-Japan Friendship Hospital，Jilin University，Jilin Province, Changchun 130051, China
Abstract：Ischemic heart disease is the disease with the highest morbidity and death rate in the world, which seriously threatens people′s life and health. Panax quinquefolium L. has been widely used in the treatment of cardiovascular diseases. It has many effects such as anti-apoptosis of myocardial cells, arrhythmia, improvement of ventricular remodeling after infarction, and enhancement of antioxidant enzyme activity. There are many studies on the protective effect of main active components of Panax quinquefolium L. on ischemic heart disease, but the mechanism is still unclear. This article reviews the mechanism of the main active ingredients of Panax quinquefolium L. in the treatment of ischemic heart disease in recent years, and expounds from a variety of perspectives, such as inhibiting myocardial cell apoptosis, improving blood circulation, and inhibiting oxidative stress. Based on this, it also provides reference value for further multi-target, multi-level development and application of Panax quinquefolium L. and the organization.
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