1.College of Pharmacy, Harbin University of Commerce, Heilongjiang Province, Harbin 150076, China;
2.College of Pharmacy, Daqing Campus, Harbin Medical University, Heilongjiang Province, Daqing 163319, China
Abstract：In recent years, tumor has been the focus of nanomedicine research, and the extracellular acidic environment of tumor provides a new idea for targeted therapy of tumor. The pH-sensitive structure changes conformation with the change of pH. The combination of pH-sensitive structure and nanostructure is used to construct the pH-sensitive nanostructure to promote the uptake of tumor cells. This paper reviews the recent research on pH-sensitive nanostructures used for tumor targeted drug delivery, describes the types of pH-sensitive nanostructures, and describes the combination of pH-sensitive structures and nanostructures. Further understanding of pH-sensitive nanostructures will help design more effective drug delivery systems to address the challenges of tumor therapy.
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2020, Vol. 17 
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