男性酒精依赖患者认知功能与红细胞相关指标的临床关系研究

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摘要目的探讨男性酒精依赖患者认知功能与红细胞相关指标的关系。方法选择2016年1月～2017年4月湖南省脑科医院收治的65例男性酒精依赖患者为研究组，65例健康体检者为对照组，采用蒙特利尔认知评估量表（MoCA）评价认知功能，全自动生化分析仪检测丙氨酸氨基转氨酶（ALT）、天冬氨酸氨基转移酶（AST）和γ-谷氨酞基转移酶（GGT）含量，全自动五分类血液细胞分析仪分析红细胞数（RBC）、血红蛋白浓度（HGB）、血细胞比容（HCT）、红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）和平均血红蛋白浓度（MCHC）等红细胞参数。结果研究组患者MoCA评分显著低于对照组，肝功能指标ALT、AST和GGT显著高于对照组，差异有统计学意义（P < 0.05）。研究组患者RBC、HGB和HCT显著低于对照组，差异有统计学意义（P < 0.05）。两组患者MCV、MCH和MCHC比较，差异无统计学意义（P > 0.05）。研究组患者MoCA评分与RBC、HGB和HCT呈正相关（r=0.61、0.63、0.72，P < 0.05），与MCV、MCH和MCHC无相关性（P > 0.05）。研究组患者ALT与RBC、HGB和HCT呈负相关（r=-0.63、-0.65、-0.73，P < 0.05），与MCV、MCH和MCHC无相关性（P > 0.05），AST和GGT与红细胞相关指标无相关性（P > 0.05）。结论男性酒精依赖患者认知功能与红细胞相关指标均发生改变，认知功能与红细胞相关指标密切相关。

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	杨俊周旭辉郭育君罗琼

关键词 ：酒精依赖, 认知功能, 红细胞指标, 相关性

Abstract：Objective To study the correlation of cognitive function and red blood cells index in male patients with alcohol dependence. Methods 65 male patients with alcohol dependence were selected as research group in Hu′nan Province Brain Hospital from January 2016 to April 2017, and 65 healthy check-up were selected as control group. The cognitive function were assessed by Montreal cognitive ment scale (MoCA), the content of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-pancreatic phthalein transferase (GGT) were tested by automatic biochemical analyzer, the red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), red cell volume (RCV), average red blood cell hemoglobin content (MCH) and hemoglobin concentration (MCHC) were detected by fully automatic classification of five blood cell analyzer. Results The score of MoCA in research group was significantly lower than that in control group, and the liver function index of ALT, AST and GGT were significantly higher than that in control group, the differences were statistically significant (P < 0.05). The RBC, HGB and HCT in research group were significantly lower than that in control group, the differences were statistically significant (P < 0.05). RCV, MCH and MCHC in two groups were no statistically significant difference (P > 0.05). The score of MoCA in research group was positive related to RBC, HGB and HCT (r = 0.61, 0.63, 0.72, P < 0.05). There were no correlation between MoCA score and MCV, MCH and MCHC in research group (P > 0.05). ALT in research group was negatively related to RBC, HGB and HCT (r =-0.63, -0.65, -0.73, P < 0.05). There was no correlation between ALT and MCV, MCH and MCHC in research group (P > 0.05). AST and GGT were not correlated with erythrocyte correlation (P > 0.05). Conclusion The cognitive function and red blood cells index in male patients with alcohol dependence are changed, the cognitive function and red blood cells index are closely related.

Key words： Alcohol dependence Cognitive function Index of red blood cells Correlation

基金资助:湖南省自然科学基金项目（2015JJ3095）。

引用本文:

杨俊周旭辉郭育君罗琼. 男性酒精依赖患者认知功能与红细胞相关指标的临床关系研究[J]. 中国医药导报, 2017, 14(26): 102-105.
YANG Jun ZHOU Xuhui GUO Yujun LUO Qiong. Clinical study on the relation of cognitive function and red blood cell index in male patient with alcohol dependence. 中国医药导报, 2017, 14(26): 102-105.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I26/102

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