基于听觉事件相关电位MMN探究意守效应差异

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摘要目的探究意守对事件相关电位失匹配负波（MMN）产生的效应差异。方法 2019年3月招募北京中医药大学东方学院72名在校大学生为研究对象，根据有无练功经验分为有经验组（A组）36名，无经验组（B组）36名，运用事件相关电位技术进行脑电监测，比较两组不同状态之间MMN潜伏期、峰值差异变化。结果 A组中MK相较于N1在额颞交界区、前颞区、额中央交界区、中央区以及顶区的MMN潜伏期缩短（P < 0.05），N2相较于N1在额极区、中颞区、额中央交界区、中央区的MMN潜伏期缩短（P < 0.05）；B组中MK相较于N1在额颞交界区的MMN潜伏期缩短（P < 0.05）。两组各状态的MMN潜伏期比较差异无统计学意义（P > 0.05）。A组中MK相较于N1在额区、前颞区、额中央交界区、中央区的MMN峰值降低（P < 0.05），N2相较于N1在前颞区的MMN峰值降低（P < 0.05）。B组各状态的MMN峰值比较差异无统计学意义（P > 0.05）。两组各状态的MMN峰值比较差异无统计学意义（P > 0.05）。结论意守可以缩短对外界刺激事物加工的时间，提高大脑自动加工的效率。

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	郭佳美1* 王莹1* 胡庆川1
	2 吕嘉轩1 郭郁1 魏泽仁1 张佳蕾2 魏玉龙1

关键词 ：气功, 意守, 事件相关电位, 失匹配负波, 认知

Abstract：Objective To explore the effect difference of mind-keeping on event-related potential mismatch negative wave (MMN). Methods In March 2019, 72 college students from Dongfang College of Beijing University of Chinese Medicine were recruited and divided into experience group (group A, n = 36) and non-experience group (group B, n = 36) according to whether they had experience or not. EEG was monitored by using event-related potential technology. The latency and peak value of MMN among different states were compared between two groups. Results In group A, the MMN latencies of MK in frontotemporal junction, anterior temporal region, frontal central junction, central region and parietal region were shorter than those of N1 (P < 0.05). In group A, the MMN latencies of N2 in frontal polar region, middle temporal region, frontal central junction area and central region were shorter than those of N1 (P < 0.05). In group B, the MMN latency of MK was shorter than that of N1 in frontotemporal junction (P < 0.05). There was no significant difference in MMN latency among different states between two groups (P > 0.05). In group A, the MMN peak value of MK in frontal region, anterior temporal area, frontal central junction area and central region was decreased compared with N1 (P < 0.05). In group A, the MMN peak of N2 in anterior temporal region was lower than that of N1 (P < 0.05). There was no significant difference in the peak value of MMN among different states in group B (P > 0.05). There was no significant difference in the peak value of MMN among different states between two groups (P > 0.05). Conclusion Mind-keeping can shorten the time for processing external information and improve the efficiency of the brain′s automatic processing.

Key words： Qigong Mind-keeping Event-related potential Mismatch negative wave Cognition

基金资助:国家自然科学基金面上项目（81674043）。

通讯作者: 魏玉龙（1971.10-），男，博士，教授，博士生导师；研究方向：气功调心机制与应用研究。

作者简介: *共同第一作者

引用本文:

郭佳美1* 王莹1* 胡庆川1,2 吕嘉轩1 郭郁1 魏泽仁1 张佳蕾2 魏玉龙1. 基于听觉事件相关电位MMN探究意守效应差异[J]. 中国医药导报, 2020, 17(30): 12-15.
GUO Jiamei1* WANG Ying1* HU Qingchuan1,2 LYU Jiaxuan1 GUO Yu1 WEI Zeren1 ZHANG Jialei2 WEI Yulong1. Difference exploration of mind-keeping effects based on auditory event-related potential MMN. 中国医药导报, 2020, 17(30): 12-15.

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