Characteristics of ultrasound and BRAFV600E gene mutation in papillary thyroid micropapillary carcinoma with cervical lymph node metastasis
ZHONG Lichang1 GU Liping1 MA Fang1 XIONG Miao2
1.Department of Ultrasound, East Branch of Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 201306, China;
2.Department of Obstetrics and Gynecology, East Branch of Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 201306, China
Abstract：Objective To analyzed ultrasonographic images of papillary thyroid micropapillary carcinoma (PTMC) with cervical lymph node metastasis and characteristics of BRAFV600E gene mutation. Methods A total of 127 cases of PTMC admitted to the East Branch of Shanghai Sixth People’s Hospital, Affiliated to Shanghai Jiaotong University from June 2013 to June 2017 were selected as study subjects. According to the presence or absence of cervical lymph node metastasis, they were divided into PTMC cervical lymph node metastasis group (61 cases) and PTMC non-cervical lymph node metastasis group (66 cases). The ultrasound characteristics and BRAFV600E gene mutation were compared between the two groups. Results There were significant differences in nodule maximum diameter, whether nodule contact with thyroid capsule, nodule shape, calcification, aspect ratio between PTMC cervical lymph node metastasis group and PTMC non-cervical lymph node metastasis group (all P < 0.05). The positive rate of BRAFV600E gene mutation in the PTMC cervical lymph node metastasis group was higher than that in the PTMC non-cervical lymph node metastasis group (P < 0.05). Conclusion In PTMC patients, cervical lymph node metastasis is likely to occur if the nodules show ultrasonic signs such as nodule maximum diameter > 5 mm, nodule contact with thyroid capsule, irregular shape of nodules, aspect ratio≥1, nodules with microcalcification, and BRAFV600E gene mutation positive.
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2020, Vol. 17 
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