Abstract：Objective To analyze the effects of oral Baitouweng Decoction combined with Mesalazine enema in the treatment of ulcerative colitis (UC). Methods One hundred and twenty patients with UC admitted to Fengrun People’s Hospital of Tangshan City from January 2017 to May 2019 were divided into control group and treatment group according to the random number table method, with 60 cases in each group. The control group was treated with Mesalazine enema, while the treatment group was treated with oral Baitouweng Decoction on the basis of the control group, with 12 weeks of treatment course. The TCM symptom scores, peripheral immune function, humoral immunity level, serum inflammatory factor levels, inflammatory bowel disease questionnaire (IBDQ) before and after treatment were compared between the two groups, and the adverse reactions during treatment were recorded. Results After treatment, the TCM symptom scores, CD8+, IgM, IgA and IgG, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) in the two groups were lower than those before treatment, which in the treatment group were significantly lower than those in the control group (all P ＜ 0.05); the CD4+, natural killer cells (NK cells), CD4+/CD8+, the scores of IBDQ in the two groups were higher than those before treatment, which in the treatment group were significantly higher than those in the control group (all P ＜ 0.05). No obvious adverse reactions occurred during the treatment of the two groups. Conclusion The efficacy of oral Baitouweng Decoction combined with Mesalazine enema in the treatment of UC is better than single-agent Mesalamine enema, and the safety is good.
聂珍静 申文静 姚蕊 王欣蕾. 白头翁汤口服联合美沙拉嗪灌肠治疗溃疡性结肠炎的效果[J]. 中国医药导报, 2020, 17(33): 149-152,169.
NIE Zhenjing SHEN Wenjing YAO Rui WANG Xinlei. Effects of oral Baitouweng Decoction combined with Mesalazine enema in the treatment of ulcerative colitis. 中国医药导报, 2020, 17(33): 149-152,169.
2020, Vol. 17 
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