Effect of vitamin A supplementation on T lymphocyte levels in peripheral blood of children with iron deficiency anemia and repeated lower respiratory infection
JIA Liyuan1 WANG Li1▲ QIAN Zengli2 WEN Li1 ZHAI Xiaoying1 QUAN Meijie1 LI Wenzi1 YANG Mingli1
1.Department of Hematology and Oncology, Hebei Children’s Hospital, Hebei Province, Shijiazhuang 050000, China;
2.Department of Nephrology, Bazhou Second Hospital, Hebei Province, Bazhou 065701, China
Abstract：Objective To explore the effect of vitamin A (VitA) supplementation on T lymphocytes levels in peripheral blood of children with iron deficiency anemia and repeated lower respiratory infection. Methods A total of 116 patients with iron deficiency anemia and repeated lower respiratory infection who admitted to Hebei Children’s Hospital from January 2017 to June 2019 were enrolled. They were divided into the observation group and the control group by random number table method, with 58 cases in each group. The control group was given routine anti-infection treatment. On this basis, the observation group was given VitA supplementation treatment. The changes in levels of anemia status indexes, T lymphocyte subsets and immunoglobulins before and after treatment were compared between the two groups. The effective rate, cough time, white blood cell count recovery normal time and hospital stay time were recorded and compared between the two groups. Results The effective rate in the observation group was higher than that in the control group (P < 0.05). After 6 months of treatment, the levels of hemoglobin, mean corpuscular volume, content of mean corpuscular hemoglobin and mean corpuscular-hemoglobin concentration in both groups were higher than those before treatment, and the observation group was higher than the control group (P < 0.05). After 6 months of treatment, the levels of CD3+, CD4+ and CD4+/CD8+ in the two groups were higher than those before treatment, while the levels of CD8+ were lower than those before treatment. The levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, while the levels of CD8+ were lower than those in the control group (P < 0.05). After 6 months of treatment, IgM, IgA and IgG levels in the two groups were higher than those before treatment and the observation group was higher than the control group (P < 0.05). The duration of cough, the time of white blood cell count recovery normal and hospital stay time in the observation group were shorter than those in the control group (all P < 0.05). Conclusion Anti-infection treatment assisted by VitA can effectively improve anemia and low immune function in children with iron deficiency anemia and repeated lower respiratory infection, shorten treatment process and accelerate their recovery.
贾丽媛1 王丽1▲ 钱增丽2 温丽1 翟小颖1 全美洁1 李文梓1 杨明丽1. 补充维生素A对缺铁性贫血伴下呼吸道反复感染患儿外周血T淋巴细胞水平的影响[J]. 中国医药导报, 2020, 17(35): 76-79.
JIA Liyuan1 WANG Li1▲ QIAN Zengli2 WEN Li1 ZHAI Xiaoying1 QUAN Meijie1 LI Wenzi1 YANG Mingli1. Effect of vitamin A supplementation on T lymphocyte levels in peripheral blood of children with iron deficiency anemia and repeated lower respiratory infection. 中国医药导报, 2020, 17(35): 76-79.
[1] 陈小燕，周卫萍.反复呼吸道感染患儿的病原菌分布与免疫功能监测[J].中华医院感染学杂志，2016，26（19）：4521-4523.
[2] Darling AM，Mugusi FM，Etheredge AJ，et al. Vitamin A and zinc supplementation among pregnant women to prevent placental malaria：a randomized，double-blind，placebo-controlled trial in tanzania [J]. Am J Trop Med Hyg，2017，96（4）：826-834.
[3] Huda MN，Ahmad SM，Alam MJ，et al. Infant cortisol stress-response is associated with thymic function and vaccine response [J]. Stress，2019，22（1）：36-43.
[4] 曹海艳，刘世平，雷媛，等.维生素A与儿童免疫功能及肺部疾病关系的研究进展[J].中国儿童保健杂志，2019， 27（2）：175-177.
[5] 齐双辉，魏兵，张超，等.维生素A对反复呼吸道感染婴幼儿的免疫调节作用研究[J].中国儿童保健杂志，2017， 25（8）：837-840.
[6] 李文迪，魏守磊，彭云，等.新生儿维生素A缺乏的研究进展[J].中国儿童保健杂志，2017，25（8）：799-802.
[7] 《中华儿科杂志》编辑委员会，中华医学会儿科学分会血液学组，中华医学会儿科学分会儿童保健学组.儿童缺铁和缺铁性贫血防治建议[J].中华儿科杂志，2008，46（7）：502-504.
[8] 中华医学会儿科学分会呼吸学组，《中华儿科杂志》编辑委员会.反复呼吸道感染的临床概念和处理原则[J].中华儿科杂志，2008，46（2）：108-110.
[9] 黄文瑞.多种微量元素佐治反复呼吸道感染患儿疗效及免疫学观察[J].中华实用儿科临床杂志，2004，19（2）：152-153.
[10] 陶泽璋，陈始明.儿童慢性鼻-鼻窦炎的精准化诊疗[J].临床耳鼻咽喉头颈外科杂志，2018，32（21）：1610-1613.
[11] 沈翎，林宗通，林兴，等.伴上呼吸道疾病的儿童慢性鼻-鼻窦炎治疗探讨[J].临床耳鼻咽喉头颈外科杂志，2017，31（6）：446-450，455.
[12] 石正英，管建宏，施益农.儿童反复呼吸道感染72例致病因素分析[J].临床肺科杂志，2017，22（9）：1711-1713.
[13] 韩允，曾玉，李青，等.维生素A水平与重症下呼吸道感染患儿临床关系的研究[J].现代预防医学，2018，45（15）：2863-2866.
[14] Rakshasbhuvankar A，Patole S，Simmer K，et al. Enteral vitamin A for reducing severity of bronchopulmonary dysplasia in extremely preterm infants：a randomised controlled trial [J]. BMC Pediatr，2017，17（1）：204.
[15] 李永强，赵婷，李贺晓，等.补充外源性维生素A、维生素E对反复呼吸道感染儿童的影响[J].中国妇幼保健，2018，33（16）：3709-3711.
[16] 李兰霞.缺铁性贫血时4项红细胞参数的变化与分析[J].检验医学与临床，2010，7（2）：153-154.
[17] Andersen AB，Schmidt LKh，Faurholt-Jepsen D，et al. The effect of daily consumption of the small fish Amblypharyngodon mola or added vitamin A on iron status：a randomised controlled trial among Bangladeshi children with marginal vitamin A status [J]. Asia Pac J Clin Nutr，2016，25（3）：464-471.
[18] 汪玲娟，孙碧霞，陈慕恒，等.维生素A联合铁制剂治疗反复呼吸道感染患儿的临床安全性及对免疫球蛋白变化的评价[J].中国药物与临床，2018，18（6）：153-155.
[19] 刘雨睿，刘静，罗娟，等.维生素AD胶囊对反复呼吸道感染儿童血清25-羟基维生素D水平、机体免疫功能及疗效的影响[J].现代预防医学，2018，45（23）：76-79.
[20] 潘筱.学龄前反复呼吸道感染儿童维生素A水平与免疫功能变化研究[J].中国妇幼保健，2015，30（35）：6241-6243.
[21] 柏翠，于晓峰，王芳，等.维生素A制剂对支气管哮喘患儿外周血辅助性T淋巴细胞17和调节性T淋巴细胞功能的影响[J].中华实用儿科临床杂志，2016，31（9）：675-678.
[22] Zenklusen I，Jongo S，Abdulla S，et al. Immunization of malaria-preexposed volunteers with PfSPZ vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies [J]. J Infect Dis，2018，217（10）：1569-1578.
[23] 张海军，董晓蕾.儿童肺炎支原体肺炎治愈1年内反复呼吸道感染的发生情况及其相关因素分析[J].山东医药，2017，57（22）：56-58.
[24] Lin CW，Tsai MH，Li ST，et al. A common glycan structure on immunoglobulin G for enhancement of effector functions [J]. Proc Natl Acad Sci U S A，2015，112（34）：10611-10616.
[25] 王雪梅，黄良富，王信伟.血清维生素A水平与儿童反复呼吸道感染及免疫功能的相关性研究[J].临床和实验医学杂志，2018，17（20）：99-102.
2020, Vol. 17 
京公网安备 11010502046598号