慢性自发性荨麻疹患者血清IL-35、IL-17和TGF-β1水平变化及临床意义

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摘要目的探讨慢性自发性荨麻疹（CSU）患者血清白细胞介素（IL）-35、IL-17与转化生长因子β1（TGF-β1）水平变化及临床意义。方法选择2016年1月—2019年1月重庆市开州区人民医院（以下简称“我院”）收治的350例CSU患者作为病例组，按照荨麻疹活动评分（UAS）分为轻度组142例、中度组124例、重度组84例，另选我院60名健康体检者作为对照组。检测血清IL-35、IL-17和TGF-β1水平，并分析其与UAS评分的关系。结果病例组血清IL-35水平显著低于对照组，IL-17和TGF-β1水平显著高于对照组，差异均有统计学意义（均P ＜ 0.05）；重度组血清IL-35水平低于中度组、轻度组，且中度组低于轻度组，差异均有统计学意义（均P ＜ 0.05）；重度组血清IL-17、TGF-β1水平高于中度组和轻度组，且中度组高于轻度组，差异均有统计学意义（均P ＜ 0.05）；Pearson相关性分析结果显示，CSU患者血清IL-35与UAS评分呈负相关（r = -0.687，P = 0.029），血清IL-17与TGF-β1水平和UAS评分呈正相关（r = 0.684、0.709，P = 0.028、0.022）。结论 CSU患者血清IL-35水平与患者病情严重程度呈负相关，IL-17与TGF-β1水平与患者病情程度呈正相关，通过检测患者血清IL-35、IL-17与TGF-β1水平可评估CSU患者病情严重程度，有利于为临床诊治提供帮助。

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	秦凯炜陶艳霞王家瑞

关键词 ：慢性自发性荨麻疹, 白细胞介素-35, 白细胞介素-17, 转化生长因子&beta, 1

Abstract：Objective To investigate the changes and clinical significance of serum levels of interleukin (IL)-35, IL-17 and transforming growth factor β1 ( TGF- β1) levels in patients with chronic spontaneous urticaria (CSU). Methods A total of 350 CSU patients admitted to the People’s Hospital of Kaizhou District of Chongqing (hereinafter referred to as “our hospital”) from January 2016 to January 2019 were selected as the case group. According to urticaria activity score (UAS), they were divided into 142 cases in mild group, 124 cases in moderate group, 84 cases in severe group, and 60 healthy subjects in our hospital were selected as the control group. Serum levels of IL-35, IL-17 and TGF-β1 were detected, and their relationship with UAS score was analyzed. Results The serum level of IL-35 in the case group was significantly lower than that in the control group, and the levels of IL-17 and TGF-β1 were significantly higher than those in the control group, with statistical significances (all P < 0.05). The serum level of IL-35 in severe group was lower than that in moderate group and mild group, and that in moderate group was lower than that in mild group, with statistical significances (all P < 0.05). The serum levels of IL-17 and TGF-β1 in severe group were higher than those in moderate group and mild group, and that in moderate group were higher than those in mild group, with statistical significances (all P < 0.05). Pearson correlation analysis results showed that serum IL-35 was negatively correlated with UAS (r = -0.687，P = 0.029), and serum IL-17 and TGF-β1 levels were positively correlated with UAS (r = 0.684, 0.709; P = 0.028, 0.022). Conclusion The serum IL-35 level of CSU patients is negatively correlated with the severity of the patient’s condition, and the levels of IL-17 and TGF-β1 are positively correlated with the severity of the patient’s condition. The detection of serum levels of IL-35, IL-17 and TGF-β1 in patients with CSU can evaluate the severity of the patient’s condition, which is helpful for clinical diagnosis and treatment.

Key words： Chronic spontaneous urticaria Interleukin-35 Interleukin-17 Transforming growth factor β1

基金资助:重庆市卫生计生委医学科研项目（2016MSXM0 67）。

通讯作者: 王家瑞（1981.11-），男，硕士，副主任医师；研究方向：皮肤烧伤。

引用本文:

秦凯炜陶艳霞王家瑞. 慢性自发性荨麻疹患者血清IL-35、IL-17和TGF-β1水平变化及临床意义[J]. 中国医药导报, 2021, 18(4): 94-97.
QIN Kaiwei TAO Yanxia WANG Jiarui. Changes of serum IL-35, IL-17 and TGF-β1 levels in patients with chronic spontaneous urticaria and their clinical significance. 中国医药导报, 2021, 18(4): 94-97.

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