Abstract：Objective To investigate clinical effect of Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Tablets in the treatment of depression. Methods By using the principle of random, controlled and blind method, a total of 90 outpatients and inpatients with depression of liver depression and spleen deficiency type in Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2018 to August 2019 were selected and divided into Western medicine group, Chinese medicine group and combination group according to the random number table method, with 30 cases in each group. Western medicine group was treated with Duloxetine Hydrochloride Enteric-coated Tablets, Chinese medicine group was treated with Xiaoyao Powder combined with Huatan Tongluo Decoction, combination group was treated with Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Enteric-coated Tablets. All patients were treated for six weeks. The curative effect of depression, curative effect of Chinese medicine symptoms, Hamilton depression scale (HAMD) score and Chinese medicine syndrome scale score before and after treatment among three groups were observed. Results Total effective rate of depression, total effective rate of Chinese medicine syndrome in combination group were higher than those in Western medicine group and Chinese medicine group (P < 0.017). Overall analysis found that there were significant differences in HAMD score and Chinese medicine syndrome scale score between inter group effect and time effect (P < 0.05), but there was no significant difference in interaction (P > 0.05). Intra group comparison: HAMD score and Chinese medicine syndrome scale score of three groups at three and six weeks after treatment were lower than those before treatment (P < 0.05). Comparison between groups: HAMD score and Chinese medicine syndrome scale score of combination group were lower than those of Western medicine group and Chinese medicine group at three and six weeks of treatment, the differences were statistically significant (P < 0.05). Conclusion Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Enteric-coated Tablets is effective in the treatment of depression, it may treat the depression as the quite ideal method clinically.
李世强 王玮 宋颖 卫景沛▲. 逍遥散合化痰通络汤加盐酸度洛西汀片治疗抑郁症的临床效果[J]. 中国医药导报, 2021, 18(4): 111-114.
LI Shiqiang WANG Wei SONG Ying WEI Jingpei▲. Clinical effect of Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Tablets in the treatment of depression. 中国医药导报, 2021, 18(4): 111-114.
2021, Vol. 18 
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