Research status of long non-coding RNA in the occurrence and development of colorectal cancer#br#
WANG Tong1* WANG Jinge2,3* JIA Chen1 HUANG Jingjing1 HUO Xiaoyan4 MENG Qinghui1 LIANG Desen1 PAN Huayang1
1.Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150001, China;
2.College of Nursing, Harbin Medical University, Heilongjiang Province, Harbin 150086, China;
3.Nursing Teaching and Research Section, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150086, China; 4.Department of Pediatrics, the First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150001, China
Abstract：Colorectal cancer is one of the most common malignant tumors of the digestive tract. Its incidence and mortality are increasing year by year. Because its early symptoms are not obvious, it is mostly in the advanced stage when it is discovered, leading to poor prognosis and survival. Long non-coding RNA is an RNA molecule, which consists of more than 200 nucleotides in length and lacks protein-coding functions, but it has a crucial regulatory role at the level of epigenetic, transcription, post-transcriptional. Studies find that long non-coding RNA is closely related to the occurrence and development of colorectal cancer, the underlying mechanism mainly includes direct binding with RNA, DNA, and protein to play a biological role. Therefore, this article describes the research progress of long non-coding RNA in colorectal cancer, which can provide a theoretical basis and practical direction for a specific diagnosis, targeted therapy and prognostic evaluation of colorectal cancer.
汪桐1* 王金格2,3* 贾晨1 黄晶晶1 霍晓燕4 孟庆辉1 梁德森1 潘华洋1. 长链非编码RNA在结直肠癌发生发展中的研究现状[J]. 中国医药导报, 2021, 18(31): 54-57.
WANG Tong1* WANG Jinge2,3* JIA Chen1 HUANG Jingjing1 HUO Xiaoyan4 MENG Qinghui1 LIANG Desen1 PAN Huayang1. Research status of long non-coding RNA in the occurrence and development of colorectal cancer#br#. 中国医药导报, 2021, 18(31): 54-57.
[1] 中华人民共和国国家健康卫生委员会.中国结直肠癌诊疗规范（2020版）[J].中华消化外科杂志，2020，19（6）：563-588.
[2] Weng M，Wu D，Yang C，et al. Noncoding RNAs in the development，diagnosis，and prognosis of colorectal cancer [J]. Transl Res，2017，181：108-120.
[3] Xie X，Tang B，Xiao YF，et al. Long non-coding RNAs in colorectal cancer [J]. Oncotarget，2016，7（5）：5226-5239.
[4] Uszczynska-Ratajczak B，Lagarde J，Frankish A，et al. Towards a complete map of the human long non-coding RNA transcriptome [J]. Nat Rev Genet，2018，19（9）：535-548.
[5] Yang Y，Zhao L，Lei L，et al. LncRNAs：the bridge linking RNA and colorectal cancer [J]. Oncotarget，2017，8（7）：12517-12532.
[6] Kopp F，Mendell JT. Functional Classification and Experimental Dissection of Long Noncoding RNAs [J]. Cell，2018，172（3）：393-407.
[7] Schmitz SU，Grote P，Herrmann BG. Mechanisms of long noncoding RNA function in development and disease [J]. Cell Mol Life Sci，2016，73（13）：2491-2509.
[8] Schmitt AM，Chang HY. Long Noncoding RNAs in Cancer Pathways [J]. Cancer Cell，2016，29（4）：452-463.
[9] Nissan A，Stojadinovic A，Mitrani-Rosenbaum S，et al. Colon cancer associated transcript-1：a novel RNA expressed in malignant and pre-malignant human tissues [J]. Int J Cancer，2012，130（7）：1598-1606.
[10] Chen S，Liu Y，Wang Y，et al. LncRNA CCAT1 Promotes Colorectal Cancer Tumorigenesis Via A miR-181b-5p/TUSC3 Axis [J]. Onco Targets Ther，2019，12：9215-9225.
[11] Ma D，Cao Y，Wang Z，et al. CCAT1 lncRNA Promotes Inflammatory Bowel Disease Malignancy by Destroying Intestinal Barrier via Downregulating miR-185-3p [J]. Inflamm Bowel Dis，2019，25（5）：862-874.
[12] Ling H，Spizzo R，Atlasi Y，et al. CCAT2，a novel noncoding RNA mapping to 8q24，underlies metastatic progression and chromosomal instability in colon cancer [J]. Genome Res，2013，23（9）：1446-1461.
[13] Gao T，Liu X，He B，et al. Exosomal lncRNA 91H is associated with poor development in colorectal cancer by modifying HNRNPK expression [J]. Cancer Cell Int，2018， 18（1）：11.
[14] Liu H，Ye D，Chen A，et al. A pilot study of new promising non-coding RNA diagnostic biomarkers for early-stage colorectal cancers [J]. Clin Chem Lab Med，2019， 57（7）：1073-1083.
[15] Wang FW，Cao CH，Han K，et al. APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production [J]. J Clin Invest，2019，129（2）：727-743.
[16] Zhu Y，Chen P，Gao Y，et al. MEG3 Activated by Vitamin D Inhibits Colorectal Cancer Cells Proliferation and Migration via Regulating Clusterin [J]. Ebio Medicine，2018，30：148-157.
[17] Wang H，Li H，Zhang L，et al. Overexpression of MEG3 sensitizes colorectal cancer cells to oxaliplatin through regulation of miR-141/PDCD4 axis [J]. Biomed Pharmacother，2018，106：1607-1615.
[18] Ding D，Li C，Zhao T，et al. LncRNA H19/miR-29b-3p/PGRN Axis Promoted Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Acting on Wnt Signaling [J]. Mol Cells，2018，41（5）：423-435.
[19] Wang M，Han D，Yuan Z，et al. Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy [J]. Cell Death Dis，2018，9（12）：1149.
[20] Luan Y，Li X，Luan Y，et al. Circulating lncRNA UCA1 Promotes Malignancy of Colorectal Cancer via the miR-143/MYO6 Axis [J]. Mol Ther Nucleic Acids，2020，19：790-803.
[21] Zhang X，Wen L，Chen S，et al. The novel long noncoding RNA CRART16 confers cetuximab resistance in colorectal cancer cells by enhancing ERBB3 expression via miR-371a-5p [J]. Cancer Cell Int，2020，20：68.
[22] Xu J，Meng Q，Li X，et al. Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p [J]. Cancer Res，2019，79（19）：4882-4895.
[23] Wang RF，Wang HY. Immune targets and neoantigens for cancer immunotherapy and precision medicine [J]. Cell Res，2017，27（1）：11-37.
[24] Sun Z，Ou C，Liu J，et al. YAP1-induced MALAT1 promotes epithelial-mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer [J]. Oncogene，2019，38（14）：2627-2644.
[25] Tang D，Yang Z，Long F，et al. Long noncoding RNA MALAT1 mediates stem cell-like properties in human colorectal cancer cells by regulating miR-20b-5p/Oct4 axis [J]. J Cell Physiol，2019，234（11）：20816-20828.
[26] Chen Q，Zhu C，Jin Y. The Oncogenic and Tumor Suppressive Functions of the Long Noncoding RNA MALAT1： An Emerging Controversy [J]. Front Genet，2020，11：93.
[27] Sun F，Liang W，Qian J. The identification of CRNDE，H19，UCA1 and HOTAIR as the key lncRNAs involved in oxaliplatin or irinotecan resistance in the chemotherapy of colorectal cancer based on integrative bioinformatics analysis [J]. Mol Med Rep，2019，20（4）：3583-3596.
[28] Pan S，Liu Y，Liu Q，et al. HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway [J]. Biochim Biophys Acta Mol Cell Res，2019，1866（5）：750-760.
[29] Tang J，Yan T，Bao Y，et al. LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc [J]. Nat Commun，2019，10（1）：3499.
[30] Feng J，Ma J，Liu S，et al. A noncoding RNA LINC00504 interacts with c-Myc to regulate tumor metabolism in colon cancer [J]. J Cell Biochem，2019，120（9）：14725-14734.
[31] Wang Y，Lu JH，Wu QN，et al. LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer [J]. Mol Cancer，2019，18（1）：174.
[32] Yang X，Zhang S，He C，et al. METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST [J]. Mol Cancer，2020，19（1）：46.
[33] Ding J，Li J，Wang H，et al. Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression [J]. Cell Death Dis，2017，8（8）：e2997.
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