Progress in the study of Bcl-2 and tumor metastasis
LIU Lei1 LI Yan2 WANG Shasha3
1.Research Center of Experimental Medicine, the Third People's Hospital of Chengdu Second Affiliated Hospital, Chongqing Medical University, Sichuan Province, Chengdu 610031, China;
2.Department of Infectious Diseases, No.42 Hospital of PLA, Sichuan Province, Leshan 614000, China; 3.Department of Biotechnology, Chengdu Medical College, Sichuan Province, Chengdu 610083, China
Abstract：Metastasis is one of the most important biological characteristics of malignant tumor, and it is the main risk factor to the patient's life. Bcl-2 is considered as a key factor in anti-apoptosis, but recent studies show that Bcl-2 may play an important role in promoting tumor metastasis. In this paper, review the function of bcl-2 in regulating cell migration, invasion and tumor metastasis and discuss associated molecular mechanism in cellular, animal models and patients levels, and also make a prospect for the therapeutic strategy to target Bcl-2, in order to provide a basis for the inhibition of tumor metastasis.
刘蕾1 李砚2 王莎莎3. Bcl-2与肿瘤转移的研究进展[J]. 中国医药导报, 2018, 15(7): 40-43.
LIU Lei1 LI Yan2 WANG Shasha3. Progress in the study of Bcl-2 and tumor metastasis. 中国医药导报, 2018, 15(7): 40-43.
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2018, Vol. 15 
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