Clinical significance of the change of peripheral blood thymidine kinase 1 in childhood acute leukemia
CHANG Zhezong1 YU Honglan2▲ FEI Ying3 YU Yunping2
1.College of Laboratory Medicine, Guizhou Medical University, Guizhou Province, Guiyang 550004, China;
2.Department of Laboratory Medicine, Guiyang First People′s Hospital, Guizhou Province, Guiyang 550002, China;
3.Department of Microbiology and Immunology, Affiliated Hospital of Guizhou Medical University, Guizhou Province, Guiyang 550004, China
Abstract：Objective To study the diagnostic value and clinical significance of serum thymidine kinase 1 (TK1) levels in different types of children with acute leukemia (AL). Methods A total of 86 children with AL from the Affiliated Hospital of Guizhou Medical University and Guiyang Children′s Hospital from October 2015 to September 2017 were selected as the study group, they were divided into acute B-cell lymphoblastic leukemia (B-ALL) group (38 cases), acute myeloid leukemia (AML) group (26 cases) and acute T-cell lymphoblastic leukemia (T-ALL) group (22 cases). At the same time, children with acute lymphoblastic leukemia (ALL) were divided into standard risk group (21 cases), intermediate-risk group (19 cases) and high risk group (20 cases), meanwhile 86 healthy children were selected as the control group. Fasting venous blood was collected and serum TK1 levels were measured. Results The levels of serum TK1 in B-ALL group, AML group and T-ALL group were higher than that of control group, the level of serum TK1 in T-ALL group was higher than that of AML group, the level of serum TK1 in AML group was higher than that of B-ALL group, with the statistically significant differences (P < 0.05). The level of serum TK1 In the high-risk group was higher than that of the intermediate-risk group, the level of serum TK1 in the intermediate-risk group was higher than that of the standard risk group, with the statistically significant differences (P < 0.05). Conclusion Detection of the level of serum TK1 has an important clinical reference value in the screening and laboratory diagnosis of AL in children. The level of serum TK1 is related to the clinical risk grade of children with ALL, which can be used as a reference index for its risk classification.
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2018, Vol. 15 
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