Abstract：Objective To discuss the influence of Xiaoqinglong Decoction on airway inflammation and clinical outcome of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 118 cases of patients with AECOPD admitted to Panyu Hospital of Chinese Medicine in Guangzhou City from January 2017 to January 2018 were enrolled as objects and divided into different groups according to critical degrees of arterial blood gas. 60 AECOPD patients without respiratory failure were included in non-respiratory failure group and 58 AECOPD patients with type Ⅱ respiratory failure were included in respiratory failure group. They were in depth grouped by random number table method: 30 cases in non-respiratory failure observation group, 30 cases in non-respiratory failure control group; 30 cases in respiratory failure observation group, 28 cases in respiratory failure control group. All patients were given standard treatment of western medicine treatment; patients of observation groups were given Xiaoqinglong Decoction for 21 days on the basis of the treatment above. Procalcitonin (PCT), interleukin 6 (IL-6) and C-reaction protein (CRP) were detected before and after treatment and 90-day follow-up was done. Serum IL-6, body mass index, airflow obstruction, dyspnea, and exercise capacity index (BODE index) at 30th, 60th, 90th day were monitored. The acute attack frequency of COPD and death events were recorded. The indices above in the observation group and control group, two observation groups and four groups were compared respectively. Results The differences in serum IL-6 and BODE index before treatment among four groups were statistically significant, and the indices were higher and the disease condition was worse in the respiratory failure group (P ＜ 0.05). The differences in serum PCT, CRP, IL-6 and BODE index between non-respiratory failure observation group and non-respiratory failure control group before treatment (first day) were not statistically significant (P ＞ 0.05). The serum CRP at 7th day and IL-6 at 90th day of non-respiratory failure observation group were decreased more obviously than those of control group, the differences were statistically significant (P ＜ 0.05). The BODE index at 90th day of non-respiratory failure observation group was improved more obviously compared with that of control group (P ＜ 0.05). The differences in serum PCT, CRP, IL-6 and BODE index between respiratory failure observation group and respiratory failure control group before treatment were not statistically significant (P ＞ 0.05). The serum PCT and CRP at 7th day of respiratory failure observation group was decreased more obviously compared with that of control group, there was statistically significant difference (P ＜ 0.05); the serum IL-6 at 30th day and 90th day were decreased more remarkably compared with those of control group, the differences were statistically significant (P ＜ 0.05). The BODE index of respiratory failure observation group at 30th, 60th, 90th day improved more obviously compared with those of control group, the differences were statistically significant (P ＜ 0.05). The number of patients that suffered from acute exacerbation of COPD in respiratory failure observation group in 90 follow-up days was less than that of control group (P ＜ 0.05). The differences in serum PCT and CRP between two observation groups before treatment were not statistically significant (P ＞ 0.05), and the difference in serum PCT at 7th day of treatment was not statistically significant (P ＞ 0.05). The difference in patients that suffered from acute exacerbation of COPD between two observation groups in 90 follow-up days was not statistically significant (P ＞ 0.05). Conclusion Xiaoqinglong Decoction can improve airway inflammation of AECOPD patients, reduce acute exacerbation frequency of AECOPD with type Ⅱ respiratory failure, and improve survival quality and clinical prognosis of AECOPD patients.
雷佩珊 苏晓茵 王强 邬志坚. 小青龙汤对慢性阻塞性肺疾病患者气道炎症及临床转归的影响[J]. 中国医药导报, 2018, 15(18): 131-135,139.
LEI Peishan SU Xiaoyin WANG Qiang WU Zhijian. Influence of Xiaoqinglong Decoction on airway inflammation and clinical outcome of patients with chronic obstructive pulmonary disease. 中国医药导报, 2018, 15(18): 131-135,139.
2018, Vol. 15 
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