Abstract：Objective To observe the application effect of Propofol in emergency tracheal intubation of patients with multiple trauma outside the hospital. Methods 194 cases of patients with multiple trauma need emergency tracheal intubation outside the hospital in Shijiazhuang Emergency Center from October 2013 to June 2015 were analyzed retrospectively. According to the methods of anesthesia, patients were divided into three groups. 65 cases in group A were given intravenous injection of Propofol before intubation; 65 cases in group B were given 2% Lidocaine Hydrochloride intratracheal superficial anesthesia before intubation; 64 cases in group C were intravenous Diazepam before intubation. Intubation preparation time, intubation completion time, pharyngeal reflectivity, one-time intubation success rate were recorded. The heart rate (HR) and blood pressure [systolic blood pressure (SBP) and diastolic blood pressure (DBP)] at before drug use (T0), endotracheal intubation immediately (T1), 1 min after intubation (T2), 3 min after intubation (T3), 5 min after intubation (T4) were observed. Results Compared with group B, the intubation preparation time, intubation completion time were shorter and the one-time intubation success rate was higher in group A (P < 0.05). Compared with group C, the intubation preparation time, intubation completion time were shorter, the one-time intubation success rate was higher, and the pharyngeal reflectivity was lower in group A (P < 0.05). Compared with T0, in the three groups at T1 the HR, SBP and DBP decreased, and in group A the decreasing was significant (P ＜ 0.05); at T2 the HR, SBP and DBP of the three groups increased, and in group B the increasing was significant (P ＜ 0.05). Conclusion Propofol intravenous injection can obviously shorten the intubation preparation time and intubation completion time, improve the success rate of intubation. Three kinds of drugs can suppress the cardiovascular response to tracheal intubation, but the effect of Propofol inhibits the changes of hemodynamic during endotracheal intubation is better.
李东旭 柳丽▲ 狄才英 赵莉娅 刘春彦 景晓. 丙泊酚在院外多发伤患者紧急气管插管中的临床应用[J]. 中国医药导报, 2017, 14(25): 69-72.
LI Dongxu LIU Li▲ DI Caiying ZHAO Liya LIU Chunyan JING Xiao. Clinical application of Propofol in emergency tracheal intubation of patients with multiple trauma outside the hospital. 中国医药导报, 2017, 14(25): 69-72.
2017, Vol. 14 
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