Abstract：Objective To explore the prognostic value of lipoprotein-related phospholipase A2 (LP-PLA2) and transcranial Doppler ultrasound (TCD) in the prognosis of acute ischemic stroke (AIS). Methods The clinical data of 171 AIS patients admitted to Nanhai Hospital of Guangdong Provincial People’s Hospital (“our Hospital” for short) from April 2017 to July 2019 were retrospectively analyzed as study group, and the physical examination data of 61 healthy volunteers who underwent physical examination in our hospital during the same period were retrospectively analyzed as control group. AIS patients were divided into mild, moderate and severe infarction patients according to the area of cerebral infarction, and LP-PLA2 and TCD parameters pulse index (PI), peak systolic flow rate (PSV) and mean blood flow velocity (MV) were compared. LP-PLA2, PI, PSV and MV were compared between the two groups. The influencing factors of poor prognosis in AIS patients were analyzed, and the predictive value of LP-PLA2, PI, PSV and the three on poor prognosis in ASI patients was analyzed. Results LP-PLA2 and PI in the study group were higher than those in the control group, while PSV and MV were lower than those in the control group (P ＜ 0.05). LP-PLA2 and PI in severe infarction patients were higher than those in mild and moderate infarction patients (P ＜ 0.05), while LP-PLA2 and PI in moderate infarction patients were higher than those in mild infarction patients (P ＜ 0.05). PSV and MV in patients with severe infarction were lower than those in patients with mild and moderate infarction (P ＜ 0.05), and PSV and MV in patients with moderate infarction were lower than those in patients with mild infarction (P ＜ 0.05). The proportion of LP-PLA2, PI and consciousness disorder in poor prognosis was higher than that in good prognosis, while PSV and MV were lower than that in good prognosis (P ＜ 0.05). LP-PLA2, PI, PSV and disturbance of consciousness were the influencing factors of poor prognosis in AIS patients (P ＜ 0.05). The area under curve values of LP-PLA2, PI, PSV and their combination in AIS patients with poor prognosis were 0.783, 0.785, 0.744, 0.915 (P ＜ 0.05). Conclusion LP-PLA2, TCD parameters PI, PSV can be used to predict the prognosis of AIS patients.
游文静1 李菁1 董燕清1 许粤燕1 黎惠贞1 郑智超2▲. LP-PLA2与经颅多普勒超声对急性缺血性脑卒中预后的预测价值[J]. 中国医药导报, 2022, 19(2): 71-74,79.
YOU Wenjing1 LI Jing1 DONG Yanqing1 XU Yueyan1 LI Huizhen1 ZHENG Zhichao2▲ . Predictive value of LP-PLA2 and transcranial Doppler ultrasound in the prognosis of acute ischemic stroke#br#. 中国医药导报, 2022, 19(2): 71-74,79.
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