Relationship between serum cytoskeleton-associated protein 4 and vascular calcification in patients with chronic kidney disease#br#
LU Hao1 ZHANG Lei1 ZHANG Xiaoyan2 XU Yongwei3 ZHOU Feixue4 LIU Xiaoju1▲
1.Department of Urology, Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province, Lishui 323000, China;
2.Hemodialysis Room, Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province, Lishui 323000, China;
3.Department of Internal Medicine-Cardiovascular, Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province, Lishui 323000, China;
4.Clinical Laboratory, Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province, Lishui 323000, China
Abstract：Objective To investigate the relationship between serum cytoskeleton-associated protein 4 (CKAP4) and vascular calcification in patients with chronic kidney disease (CKD). Methods A total of 153 CKD patients admitted to Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province from January 2019 to April 2021 were selected and they were divided into calcification group (52 cases) and non-calcification group (101 cases) according to the vascular calcification. The clinical data, serum calcium, serum phosphorus, parathyroid hormone (PTH), matrix metalloproteinase-2 (MMP-2), and serum CKAP4 levels were compared between the two groups. Logistic regression model was used to analyze the relationship between serum CKAP4 level and vascular calcification in patients with CKD. The predictive value of serum CKAP4 level on vascular calcification in patients with CKD was analyzed by receiver operation characteristic (ROC) curve. Results The course of disease in calcified group was longer than that in non-calcified group, and the stage of CKD was higher than that in non-calcified group, the levels of serum CKAP4 in calcified group were lower than those in non-calcified group, and the levels of serum calcium, serum phosphorus, PTH, and MMP-2 were higher than those in non-calcified group, the differences were statistcally significant (P ＜ 0.05). Multivariate results showed that CDK stage, blood calcium, blood phosphorus, PTH, MMP-2, and CKAP4 were independent influencing factors of vascular calcification in patients with CKD (P ＜ 0.05). The area under the ROC curve for predicting vascular calcification in patients with CKD by serum CKAP4 level was 0.823 (P ＜ 0.05), the sensitivity was 84.62%, the specificity was 72.28%, the Youden index was 0.569, and the cut-off value was 173.50 pg/ml. Conclusion The decreased serum CKAP4 level in patients with CKD is an independent factor affecting the occurrence of vascular calcification, which can be used as a predictor of vascular calcification in CKD.
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