Analysis of the drug rule of Feng Jianhua in the treatment of diabetes mellitus type 2 based on data mining
NI Linlin1 XU Yunsheng2 ZHOU Honglei3#br#
1.Department of Reproductive Medicine, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250001, China;
2.College of Pharmacy, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250355, China;
3.Department of Endocrinology, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250001, China
Abstract：
[Abstract] Objective To analyze the drug rule and characteristics of Professor Feng Jianhua in the treatment of diabetes mellitus type 2, and to provide reference for the treatment of diabetes mellitus with traditional Chinese medicine. Methods The outpatient traditional Chinese medicine prescription data of Professor Feng Jianhua in the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine for the treatment of diabetes mellitus type 2 patients from January 2000 to December 2020 were collected from the database of Famous Doctor Inheritance System jointly developed by Beijing University of Chinese Medicine and Institute of Computing Technology, Chinese Academy of Sciences. Through data analysis, drug use frequency, drug taste and channel frequency were counted, common drug pairs were found through association analysis, and core prescriptions were extracted by constructing drug relationship network graph. Results A total of 120 patients with diabetes mellitus type 2 were included in this study, and 96 Chinese medicines were used in total. The top five ingredients of drug frequency were unprocessed Rehmanniae Radix, Coptidis Rhizoma, Anemarrhenae Rhizoma, corn stigma, and Salviae Miltiorrhizae Radix Et Rhizoma. The top five drug tastes were sweet, bitter, pungent, sour, and tasteless. The top five channel tropism frequencies were liver, lung, kidney, stomach, and spleen channels. The most common drug was unprocessed Gypsum Fibrosum-Anemarrhenae Rhizoma. The core prescription was unprocessed Rehmanniae Radix, Salviae Miltiorrhizae Radix Et Rhizoma, corn stigma, Coptidis Rhizoma, Anemarrhenae Rhizoma, Schisandrae Chinensis Fructus, unprocessed Gypsum Fibrosum, Puerariae Lobatae Radix. Conclusion Professor Feng is good at using replenishing the vital essence and removing heat drugs in the treatment of diabetes mellitus. The drug tastes are mostly sweet and bitter, Gypsum Fibrosum-Anemarrhenae Rhizoma are most often used together.
倪琳琳1 徐云生2 周洪雷3. 基于数据挖掘的冯建华名老中医治疗2型糖尿病用药规律分析[J]. 中国医药导报, 2022, 19(18): 102-105,118.
NI Linlin1 XU Yunsheng2 ZHOU Honglei3. Analysis of the drug rule of Feng Jianhua in the treatment of diabetes mellitus type 2 based on data mining. 中国医药导报, 2022, 19(18): 102-105,118.
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