1.Department of Gastroenterology, Xishan Traditional Chinese Medicine Hospital of Wuxi, Jiangsu Province, Wuxi 214194, China;
2.Institute of Clinical Immunology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 3.Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Jiangsu Province, Wuxi 214062, China
[Abstract] Objective To observe the effect of external application of Chanxiong Plaster on gastric cancer pain with syndrome of blood stasis and heat toxin. Methods A total of 72 patients with gastric cancer pain with syndrome of blood stasis and heat toxin treated in Xishan Traditional Chinese Medicine Hospital of Wuxi, Jiangsu Province from January 2019 to July 2021 were selected as the research subjects, according to random number table method, they were divided into observation group and control group, with 36 cases in each group. The control group was treated with three-step standard treatment, and the observation group was treated with external application of Chanxiong Plaster. After one week, the clinical efficacy, pain relief onset time, pain relief duration time, burst pain times, traditional Chinese medicine syndrome score were compared. Serum 5-hydroxytryptamine (5-HT) and β-endorphin (β-EP) levels were detected before and after treatment, and the safety was evaluated. Results In the observation group, 34 cases were observed and two cases were fell off. In the control group, 33 cases were observed and three cases were fell off. The clinical efficacy of the observation group was better than that of the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the onset time of pain relief and the outbreak times of pain in the observation group were shorter than those in the control group (P ＜ 0.05); the duration time of pain relief in the observation group was longer than that in the control group, the difference was statistically significant (P ＜ 0.05). After treatment, and the scores of traditional Chinese medicine syndrome in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the serum 5-HT contents in both groups were lower than those before treatment, and that in the observation group was lower than that in the control group, while the β-EP contents in both groups were increased, and that in the observation group was higher than that in the control group, the difference was statistically significant (P ＜ 0.05). In this study, two patients in observation group showed symptoms of pruritus and mild edema at the application site after treatment, which disappeared after external application of Qingdai Powder. No obvious adverse events were observed in control group. Conclusion External application of Chanxiong Plaster can effectively treat gastric cancer pain with syndrome of blood stasis and heat toxin without obvious adverse reactions, and it is worthy of clinical promotion.
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