Effects of stored autologous component transfusion and whole blood transfusion on immune function and hemorheology of Rh(D)-negative perinatal pregnant women
JIANG Hui GU Xiaowen WANG Yue▲
Department of Blood Transfusion, the Affiliated Huaian NO.1 Hospital of Nanjing Medical University, Jiangsu Province, Huaian 223300, China
Abstract：Objective To investigate the effects of stored autologous component transfusion and whole blood transfusion on immune function and hemorheology of Rh(D)-negative perinatal pregnant women. Methods A total of 98 Rh(D）-negative perinatal pregnant women who were treated in the Affiliated Huaian NO.1 Hospital of Nanjing Medical University from August 2016 to August 2021 were selected. They were divided into study group and conventional group by random number table method, with 49 cases in each group. The conventional group was treated with stored autologous whole blood transfusion, and study group was treated with stored autologous component transfusion. Immune function index, erythrocyte deformed index (EDI), low blood viscosity (LBV), mean blood viscosity, red blood cell count, hematocrit (HCT), and erythrocyte aggregation index (EAI) before blood transfusion and three days after blood transfusion between two groups were compared; pregnancy outcomes and adverse reactions between two groups were observed. Results Three days after transfusion, CD4+ and CD4+/CD8+ in two groups were lower than those before blood transfusion, and those of study group were higher than those of conventional group (P < 0.05); CD8+ was higher than that before blood transfusion, and that of study group was higher than that of conventional group (P < 0.05). Three days after transfusion, LBV and average blood viscosity in two groups were lower than those before transfusion, and those in study group were lower than those in conventional group (P < 0.05); EDI of two groups was higher than that before blood transfusion, and that of study group was lower than that of conventional group (P < 0.05). Three days after transfusion, red blood cell count, HCT, and EAI in two groups were lower than those before blood transfusion, and those in study group were lower than those in conventional group (P < 0.05). There were no significant differences in blood loss at 24 h after delivery, Apgar score at five minutes, and length of hospital stay between two groups (P > 0.05). No allergic reaction occurred in both groups. There was no significant difference in the total incidence of adverse reactions between two groups (P > 0.05). Conclusion Compared with stored autologous whole blood transfusion, stored autologous component transfusion has better effects on immune function indexes and hemorheology of Rh(D）-negative perinatal pregnant women, can improve blood indexes, and is safe and reliable.
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