Activation and exhaustion of CD8+ memory T cells in human immunodeficiency virus infected patients after anti-retroviral therapy
QIU Wenhao1 XIONG Runsong2 LIU Xian3 WU Yuerong4 XIAO Jian3
1.School of Basic Medicine, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530022, China;
2.School of Public Health and Management, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530022, China; 3.Science and Technology Division, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530022, China;
4.Scientific Experiment Center, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530022, China
[Abstract] Objective To investigate the level of activation and exhaustion of CD8+ memory T cells (Tm) in human immunodeficiency virus (HIV) infected patients after anti-retroviral therapy (ART). Methods From January to February 2022, 62 HIV-infected patients (divided into incomplete immune reestablishment group [22 cases] and complete immune reestablishment group [40 ceaes] after ART treatment and 12 healthy subjects were selected in Guigang Center for Disease Control and Prevention, Guangxi. The activation and depletion levels of CD8+Tm cells in HIV-infected patients were detected. Results The expression levels of CD38, HLA-DR, and 2B4 in CD8+Tm cells in the incomplete immune reestablishment group and complete immune reestablishment group were higher than those in the healthy group (P ＜ 0.05). The expression of 2B4 in CD38+HLA-DR+CD8+Tm cells in immune reestablishment group and complete immune-reestablishment group were significantly higher than that in healthy group (P ＜ 0.05). There was a positive correlation between CD38 and HLA-DR expression in CD8+Tm cells of HIV-infected patients (r = 0.634 6, P ＜ 0.05). Conclusion Although the HIV infected patients received the treatment of CD8+Tm cells after art, the activation of CD8+Tm cells still increased, which led to the overexpression of immune exhaustion molecules and the suppression of immune function.
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