Effect of target-oriented management of regional cerebral oxygen saturation monitoring on early cognitive function in the elderly after laparoscopic radical resection of colorectal cancer under general anesthesia
WANG Jing WANG Jie
Department of Anesthesiology, Suzhou Ninth People’s Hospital, Jiangsu Province, Suzhou 215200, China
Abstract：Objective To explore the effect of target-oriented management of regional cerebral oxygen saturation (rScO2) monitoring on early cognitive function in the elderly after laparoscopic radical resection of colorectal cancer under general anesthesia. Methods Ninety-two elderly patients with colorectal cancer admitted to Suzhou Ninth People's Hospital, Jiangsu Province, from January 2020 to December 2021 were selected as research objects. They were divided into control group and study group, with 46 cases in each group. The control group received routine anesthesia monitoring management, and study group was combined with rScO2 monitoring on the basis of control group. The cognitive function of two groups before operation and 24 h after operation were compared; heart rate, mean arterial pressure (MAP), lactate level, and body temperature were compared before operation (T0), 30 min after anesthesia (T1) and 5 min after extubation (T2); 24 h postoperative analgesia was compared between two groups; the occurrence of perioperative adverse reactions was recorded in two groups. Results The scores of mini-mental state examination scale 24 h after operation in two groups were lower than those before operation, and study group was higher than control group, and the differences were statistically significant (P＜0.05). At T2, heart rate of study group was lower than that at T0 and T1; MAP and lactic acid were higher than those at T0 and T1, and the differences were statistically significant (P＜0.05). At T1, heart rate of study group was lower than that that at T0; lactic acid was higher than that at T0, and the differences were statistically significant (P＜0.05). At T2, heart rate and MAP of control group was lower than that at T0; lactic acid were higher than those at T0 and T1, and the differences were statistically significant (P＜0.05). At T1, heart rate of control group was lower than that at T0, MAP and lactic acid were higher than those at T0, and the differences were statistically significant (P＜0.05). At T2, lactic acid in study group was lower than that in control group, and the difference was statistically significant (P＜0.05); at T1, MAP of study group was higher than that of control group, and lactic acid was lower than that of control group, and the differences were statistically significant (P＜0.05). There was no significant difference in body temperature between two groups at different time points (P＞0.05). There was no significant difference in 24 h postoperative analgesic effect between two groups (P＞0.05). There was no significant difference in the total incidence of perioperative adverse reactions between two groups (P＞0.05). Conclusion Target-oriented management of rScO2 monitoring should be used in radical resection of colorectal cancer in elderly patients under general anesthesia to help reduce the risk of postoperative cognitive dysfunction in patients.
王静 王洁. 脑氧饱和度监测目标导向管理对老年全麻下腹腔镜结直肠癌根治术后早期认知功能的影响[J]. 中国医药导报, 2023, 20(4): 120-123.
WANG Jing WANG Jie. Effect of target-oriented management of regional cerebral oxygen saturation monitoring on early cognitive function in the elderly after laparoscopic radical resection of colorectal cancer under general anesthesia. 中国医药导报, 2023, 20(4): 120-123.
京公网安备 11010502046598号