Clinical effect of Xiaohe Tongqiao Prescription on adenoid hypertrophy of phlegm-stasis interjunction type in children
QIAO Shunan1 ZHU Shan2 ZHANG Ya1 LI Xinyang1
1.Medicial College of Pediatrics, Henan University of Chinese Medicine, Henan Province, Zhengzhou 450000, China;
2.Department of Pediatrics, Henan Provincial Hospital of Traditional Chinese Medicine，Henan Province, Zhengzhou 450000, China
Abstract：Objective To explore the clinical effect of Xiaohe Tongqiao Prescription on adenoid hypertrophy of phlegm-stasis interjunction type in children. Methods A total of 77 adenoid hypertrophy with phlegm-stasis interjunction type in Henan Provincial Hospital of Traditional Chinese Medicine from January to December 2021 were selected, they were divided into treatment group (39 cases) and control group (38 cases) according to the random number table method. The treatment group was given Xiaohe Tongqiao Prescription, and the control group was given Mometasone Furoate Nasal Spray and Montelukast Sodium Chewable Tablet. After four weeks, the clinical efficacy, traditional Chinese medicine syndrome score, quality-of-life, adenoid volume A/N score, interleukin (IL)-4, IL-6, eosinophilic percentage (EOS%), and serum total immunoglobulin E (IgE) between two groups were compared, and adverse reactions and recurrence rates between two groups were observed. Results The clinical effect of treatment group was better than that of control group (P＜0.05). After treatment, the scores of night sleep snoring, open mouth breathing, nasal congestion, cough and sputum, sore throat, nausea, head and body sleepiness, breathing and awakening, and face of two groups were lower than those before treatment, and treatment group was lower than control group (P＜0.05). After treatment, the scores of the OSA-18 scale in both groups were lower than those before treatment, and the treatment group was lower than the control group (P＜0.05). After treatment, the scores of A/N of two groups were lower than those before treatment, and treatment group was lower than control group (P＜0.05). After treatment, the levels of IL-4 and IL-6 in both groups were lower than those before treatment, and treatment group was lower than control group (P＜0.05). After treatment, EOS% and serum total IgE in both groups were lower than those before treatment, and EOS% in treatment group was lower than that in control group (P＜0.05). Conclusion Xiaohe Tongqiao Prescription has remarkable effect on adenoid hypertrophy of phlegm-stasis interjunction type in children.
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