Abstract：Objective To compare the effects of Canagliflozin and Metformin in type 2 diabetes mellitus (T2DM) combined with mild obstructive sleep apnea hypopnea syndrome (OSAHS). Methods Sixty patients with T2DM complicated with mild OSAHS admitted to Baise People’s Hospital of Guangxi Zhuang Autonomous Region from June 2020 to June 2021, according to random number table method, they were divided into Canagliflozin group and Metformin group, with 30 cases in each group. Canagliflozin group received Canagliflozin orally and Metformin group received Metformin orally, all were treated for 12 weeks. Blood glucose index, blood lipid index, body mass index (BMI), blood pressure, ventilation function, and the occurrence of adverse reactions were compared between the two groups before and after treatment. Results After treatment, fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin, and insulin resistance index of the two groups were lower than before treatment, the differences were statistically significant (P＜0.05), but there was no statistical significance between the two groups (P＞0.05). After treatment, total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in both groups were lower than before treatment, while high density lipoprotein cholesterol (HDL-C) was higher than before treatment, and TC, TG, and LDL-C in Canagliflozin group were lower than those in Metformin group, while HDL-C was higher than those in Metformin group. After treatment, BMI, systolic blood pressure, diastolic blood pressure, and apnea hypopnea index (AHI) in Canagliflozin group were lower than before treatment, and lowest percutaneous arterial oxygen saturation (LSpO2) was higher than before treatment, and BMI, systolic blood pressure, diastolic blood pressure, and AHI in Canagliflozin group were lower than those in Metformin group, while LSpO2 was higher than those in Metformin group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Compared with Metformin, Canagliflozin can not only effectively improve blood glucose and lipid levels in T2DM patients with mild OSAHS, but also effectively improve blood pressure, ventilation function and weight loss.
杨斌1 余飞2▲ 王勇1 潘美时1 林之源1. 卡格列净和二甲双胍在2型糖尿病合并轻度阻塞性睡眠呼吸暂停综合征中的应用效果[J]. 中国医药导报, 2023, 20(14): 118-122.
YANG Bin1 YU Fei2▲ WANG Yong1 PAN Meishi1 LIN Zhiyuan1. Efficacy of Canagliflozin and Metformin in type 2 diabetes mellitus combined with mild obstructive sleep apnea syndrome. 中国医药导报, 2023, 20(14): 118-122.
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